An advanced multifunctional prodrug combining photodynamic therapy with chemotherapy for highly efficient and precise tumor ablation
It is urgently required to develop the molecular agents with high therapeutic efficacy and low
side effects for precise cancer therapy. Herein, an advanced multifunctional prodrug B-BDP …
side effects for precise cancer therapy. Herein, an advanced multifunctional prodrug B-BDP …
Enzyme-activated multifunctional prodrug combining site-specific chemotherapy with light-triggered photodynamic therapy
HX Zhang, HH Lin, D Su, DC Yang… - Molecular …, 2022 - ACS Publications
Combination treatments are more effective than conventional monotherapy in combating
cancer. Herein, a multifunctional prodrug BDP-L-CPT was rationally engineered and …
cancer. Herein, a multifunctional prodrug BDP-L-CPT was rationally engineered and …
Red light triggered photodynamic-chemo combination therapy using a prodrug caged by photosensitizer
G Xu, HX Zhang, XQ Li, DC Yang, JY Liu - European Journal of Medicinal …, 2021 - Elsevier
Abstract Development of the drug with high therapeutic efficacy and low toxicity is crucial to
cancer ablation. In this study, we have demonstrated a red light-responsive prodrug BDP-TK …
cancer ablation. In this study, we have demonstrated a red light-responsive prodrug BDP-TK …
A promising strategy for synergistic cancer therapy by integrating a photosensitizer into a hypoxia-activated prodrug
DC Yang, XZ Yang, CM Luo, LF Wen, JY Liu… - European Journal of …, 2022 - Elsevier
Herein, we fabricate a multifunctional molecular prodrug BAC where the chemotherapeutical
agent camptothecin (CPT) is linked with a boron dipyrromethene (BODIPY)-based …
agent camptothecin (CPT) is linked with a boron dipyrromethene (BODIPY)-based …
A glutathione activatable pro-drug-photosensitizer for combined chemotherapy and photodynamic therapy
Y Yang, Y Zhang, R Wang, X Rong, T Liu, X Xia… - Chinese Chemical …, 2022 - Elsevier
During cancer treatment, chemotherapeutic drugs always result in severe side-effects and
drug resistance. Therefore, combining cheomtherapy with other therapeutic modalities, such …
drug resistance. Therefore, combining cheomtherapy with other therapeutic modalities, such …
Rational Design of Efficient Heavy-Atom-Free Boron-Dipyrromethene Nanophotosensitizers for Two-Photon Excited Photodynamic Therapy of Cancer
VN Nguyen, DJ Lee, D Zhang, J Ha… - Chemistry of …, 2024 - ACS Publications
Although boron-dipyrromethene (BODIPY) dyes have been widely recognized for their
potential use as photosensitizers (PSs) in cancer treatment, the development of heavy-atom …
potential use as photosensitizers (PSs) in cancer treatment, the development of heavy-atom …
PEG conjugated BODIPY-Br 2 as macro-photosensitizer for efficient imaging-guided photodynamic therapy
Drug-free biocompatible nanoparticles with photosensitizers as both diagnostic and therapy
agents represent an emerging approach for imaging-guided photodynamic therapy (PDT) …
agents represent an emerging approach for imaging-guided photodynamic therapy (PDT) …
Coupling Chlorin-Based Photosensitizers and Histone Deacetylase Inhibitors for Photodynamic Chemotherapy
L Hou, Y Zhang, Y Huang, Z Fang, G Sang… - Molecular …, 2022 - ACS Publications
Photodynamic therapy combined with chemotherapy is a promising strategy to improve the
antitumor efficacy. On the basis of coupling the chlorin-based photosensitizer …
antitumor efficacy. On the basis of coupling the chlorin-based photosensitizer …
PEGylated dimeric BODIPY photosensitizers as nanocarriers for combined chemotherapy and cathepsin B-activated photodynamic therapy in 3D tumor spheroids
S Lu, X Lei, H Ren, S Zheng, J Qiang… - ACS Applied Bio …, 2020 - ACS Publications
The development of enzyme-activatable photosensitizers and their combination with
conventional chemodrugs for antitumor therapy are of great interest. In this work, we …
conventional chemodrugs for antitumor therapy are of great interest. In this work, we …
[HTML][HTML] Cell membranes targeted unimolecular prodrug for programmatic photodynamic-chemo therapy
J Yuan, R Peng, D Su, X Zhang, H Zhao, X Zhuang… - Theranostics, 2021 - ncbi.nlm.nih.gov
Photodynamic therapy (PDT) has emerged as one of the most up-and-coming non-invasive
therapeutic modalities for cancer therapy in rencent years. However, its therapeutic effect …
therapeutic modalities for cancer therapy in rencent years. However, its therapeutic effect …
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