The proteome refers to the collection of proteins in a given biological organism or system
under a particular set of environmental conditions. The study of proteins, referred to as …

Mass spectrometry (MS) is the most comprehensive and versatile tool in large-scale
proteomics. In this review, we dissect the overall framework of the MS experiment into its key …

Proteomics represents a significant challenge to separation scientists because of the
diversity and complexity of proteins and peptides present in biological systems. Mass …

Sample complexity and dynamic range constitute enormous challenges in proteome
analysis. The back-end technology in typical proteomics platforms, namely mass …

This review covers recent developments towards the implementation of multi-dimensional
(MuD) liquid phase based systems for proteome investigations. Although two-dimensional …

The present review attempts to cover the vast array of methods which have appeared in the
last few years for performing quantitative proteome analysis. These methods are divided into …

Shortcomings in two-dimensional gel electrophoresis have encouraged the search for new
methods of high-throughput proteome analysis. A variety of chromatographic methods can …

Multidimensional peptide separation will play an increasingly important role in the drive to
identify and quantitate the proteome. By increasing the peak and load capacity …

Multidimensional chromatography coupled to mass spectrometry is an emerging technique
for the analysis of complex protein mixtures. One approach in this general category …

In clinical and diagnostic proteomics, it is essential to develop a comprehensive and robust
system for proteome analysis. Although multidimensional liquid chromatography/tandem …