Repurposing bioactive aporphine alkaloids as efflux pump inhibitors
Extrusion of drugs or drug-like compounds through bacterial efflux pumps is a serious health
issue that leads to loss in drug efficacy. Combinatorial therapies of low-efficacy drugs with …
issue that leads to loss in drug efficacy. Combinatorial therapies of low-efficacy drugs with …
Carvacrol Enhances the Antimicrobial Potency of Berberine in Bacillus subtilis
The essential oil carvacrol from oregano displays a wide range of biological activities among
which is found the inhibition of efflux pumps. Thus, using carvacrol, the current work …
which is found the inhibition of efflux pumps. Thus, using carvacrol, the current work …
Phytochemicals increase the antibacterial activity of antibiotics by acting on a drug efflux pump
T Ohene‐Agyei, R Mowla, T Rahman… - …, 2014 - Wiley Online Library
Drug efflux pumps confer resistance upon bacteria to a wide range of antibiotics from
various classes. The expression of efflux pumps are also implicated in virulence and biofilm …
various classes. The expression of efflux pumps are also implicated in virulence and biofilm …
[HTML][HTML] Inhibiting bacterial drug efflux pumps via phyto-therapeutics to combat threatening antimicrobial resistance
Antibiotics, once considered the lifeline for treating bacterial infections, are under threat due
to the emergence of threatening antimicrobial resistance (AMR). These drug-resistant …
to the emergence of threatening antimicrobial resistance (AMR). These drug-resistant …
Hormesis Effect of Berberine against Klebsiella pneumoniae Is Mediated by Up-Regulation of the Efflux Pump KmrA
Y Li, H Wen, X Ge - Journal of Natural Products, 2021 - ACS Publications
Berberine (BBR) is an effective drug for human intestinal inflammation by preventing
intestinal adhesion of bacterial pathogens, while its antibacterial activity is ineffective …
intestinal adhesion of bacterial pathogens, while its antibacterial activity is ineffective …
N-caffeoylphenalkylamide derivatives as bacterial efflux pump inhibitors
S Michalet, G Cartier, B David, AM Mariotte… - Bioorganic & medicinal …, 2007 - Elsevier
As part of an ongoing project to identify plant natural products as efflux pump inhibitors
(EPIs), bioassay-guided fractionation of the methanolic extract of Mirabilis jalapa …
(EPIs), bioassay-guided fractionation of the methanolic extract of Mirabilis jalapa …
Role of Berberine as a Potential Efflux Pump Inhibitor against MdfA from Escherichia coli: In Vitro and In Silico Studies
Y Li, X Ge - Microbiology Spectrum, 2023 - Am Soc Microbiol
Infections by Gram-negative pathogens are usually difficult to manage due to the drug export
by efflux pumps. With the evolution and horizontal transfer of efflux pumps, there is an urgent …
by efflux pumps. With the evolution and horizontal transfer of efflux pumps, there is an urgent …
Evaluation of a series of 2-napthamide derivatives as inhibitors of the drug efflux pump AcrB for the reversal of antimicrobial resistance
Y Wang, R Mowla, L Guo, AD Ogunniyi… - Bioorganic & medicinal …, 2017 - Elsevier
Drug efflux pumps confer multidrug resistance to dangerous pathogens which makes these
pumps important drug targets. We have synthesised a novel series of compounds based on …
pumps important drug targets. We have synthesised a novel series of compounds based on …
Discovery of multidrug efflux pump inhibitors with a novel chemical scaffold
AT Green, M Moniruzzaman, CJ Cooper… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Multidrug efflux is a major contributor to antibiotic resistance in Gram-negative bacterial
pathogens. Inhibition of multidrug efflux pumps is a promising approach for reviving the …
pathogens. Inhibition of multidrug efflux pumps is a promising approach for reviving the …
Chlorpromazine and amitriptyline are substrates and inhibitors of the AcrB multidrug efflux pump
Efflux is an important mechanism in Gram-negative bacteria conferring multidrug resistance.
Inhibition of efflux is an encouraging strategy to restore the antibacterial activity of antibiotics …
Inhibition of efflux is an encouraging strategy to restore the antibacterial activity of antibiotics …