Simple Summary Multidrug-resistant bacterial infections, especially that caused by Gram-
negative bacteria, have posed serious health issues worldwide. Bacteria have different …

Efflux by resistance nodulation cell division transporters, such as AcrAB-TolC in Escherichia
coli, substantially contributes to the development of Gram-negative multidrug resistance …

Multidrug resistance (MDR) refers to the capability of bacterial pathogens to withstand lethal
doses of structurally diverse drugs which are capable of eradicating non-resistant strains …

Bacterial multidrug resistance (MDR) has become a major public health threat. Along with
enzymatic modifications, overexpression of MDR efflux pumps is a significant antibiotic …

Drug resistant bacteria is an increasingly urgent challenge to public health. Bacteria
adaptation and extensive abuse of antibiotics contribute to this dilemma. Active efflux of …

Antimicrobial resistance represents a significant challenge to future healthcare provision. An
acronym ESKAPEE has been derived from the names of the organisms recognised as the …

Ever increasing numbers of antibiotic resistances are putting more and more pressure on
research and global health systems. Multidrug-resistant bacteria even escape from second …

The worldwide dissemination of «multi-drug resistant»(MDR) pathogens has severely
reduced the efficacy of our antibiotic arsenal and increased the frequency of therapeutic …

Bacterial resistance to antibiotics is a serious threat to public health, with” superbugs” such
as MRSA (methicillin-resistant Staphylococcus aureus) responsible for nearly as many …

Active efflux of antibiotics preventing their accumulation to toxic intracellular concentrations
contributes to clinically relevant multidrug resistance. Inhibition of active efflux potentiates …