Medicinal chemistry updates on bacterial efflux pump modulators
F Durães, M Pinto, E Sousa - Current Medicinal Chemistry, 2018 - ingentaconnect.com
Antibiotic resistance is one of the most pressing health issues of our days. It can arise due to
a multiplicity of factors, such as target modification, decrease in the drug uptake, changes in …
a multiplicity of factors, such as target modification, decrease in the drug uptake, changes in …
A comprehensive review on pharmacology of efflux pumps and their inhibitors in antibiotic resistance
V Thakur, A Uniyal, V Tiwari - European Journal of Pharmacology, 2021 - Elsevier
The potential for the build-up of resistance to a particular antibiotic endangers its therapeutic
application over time. In recent decades, antibiotic resistance has become one of the most …
application over time. In recent decades, antibiotic resistance has become one of the most …
Importance of efflux pumps in subjugating antibiotic resistance
Antibiotic resistance is defined as a condition that assists any disease-causing organism to
resist antibiotics of different class with distinct structure and function directed for its …
resist antibiotics of different class with distinct structure and function directed for its …
New roads leading to old destinations: efflux pumps as targets to reverse multidrug resistance in bacteria
Multidrug resistance (MDR) has appeared in response to selective pressures resulting from
the incorrect use of antibiotics and other antimicrobials. This inappropriate application and …
the incorrect use of antibiotics and other antimicrobials. This inappropriate application and …
[HTML][HTML] Suppl 1: Pimozide inhibits the AcrAB-TolC efflux pump in Escherichia coli
JA Bohnert, S Schuster, WV Kern - The open microbiology journal, 2013 - ncbi.nlm.nih.gov
Efflux pump inhibitors (EPIs) are attractive compounds to reverse multidrug-resistance in
clinically relevant bacterial pathogens. In this study we tested the ability of the neuroleptic …
clinically relevant bacterial pathogens. In this study we tested the ability of the neuroleptic …
RND Efflux Pump Induction: A Crucial Network Unveiling Adaptive Antibiotic Resistance Mechanisms of Gram-Negative Bacteria
M Novelli, JM Bolla - Antibiotics, 2024 - mdpi.com
The rise of multi-drug-resistant (MDR) pathogenic bacteria presents a grave challenge to
global public health, with antimicrobial resistance ranking as the third leading cause of …
global public health, with antimicrobial resistance ranking as the third leading cause of …
Metabolomics reveal potential natural substrates of AcrB in Escherichia coli and Salmonella enterica Serovar Typhimurium
In the fight against antibiotic resistance, drugs that target resistance mechanisms in bacteria
can be used to restore the therapeutic effectiveness of antibiotics. The multidrug resistance …
can be used to restore the therapeutic effectiveness of antibiotics. The multidrug resistance …
Reserpine is the new addition into the repertoire of AcrB efflux pump inhibitors
Acriflavine resistance protein B (AcrB) serves as prototype for multidrug resistance (MDR)
efflux transporters of resistance nodulation division (RND) superfamily. AcrB has been …
efflux transporters of resistance nodulation division (RND) superfamily. AcrB has been …
Molecular cloning and characterization of SmrA, a novel ABC multidrug efflux pump from Stenotrophomonas maltophilia
A Al-Hamad, M Upton, J Burnie - Journal of antimicrobial …, 2009 - academic.oup.com
Objectives Stenotrophomonas maltophilia is an emerging nosocomial pathogen that can
cause difficult-to-treat infections and exhibits significant degrees of poorly understood …
cause difficult-to-treat infections and exhibits significant degrees of poorly understood …
Phenolic compound ethyl 3, 4-dihydroxybenzoate retards drug efflux and potentiates antibiotic activity
WJ Lu, YJ Huang, HJ Lin, CJ Chang, PH Hsu, GX Ooi… - Antibiotics, 2022 - mdpi.com
The World Health Organization indicated that antibiotic resistance is one of the greatest
threats to health, food security, and development in the world. Drug resistance efflux pumps …
threats to health, food security, and development in the world. Drug resistance efflux pumps …