Medicinal chemistry updates on bacterial efflux pump modulators

F Durães, M Pinto, E Sousa - Current Medicinal Chemistry, 2018 - ingentaconnect.com
Antibiotic resistance is one of the most pressing health issues of our days. It can arise due to
a multiplicity of factors, such as target modification, decrease in the drug uptake, changes in …

A comprehensive review on pharmacology of efflux pumps and their inhibitors in antibiotic resistance

V Thakur, A Uniyal, V Tiwari - European Journal of Pharmacology, 2021 - Elsevier
The potential for the build-up of resistance to a particular antibiotic endangers its therapeutic
application over time. In recent decades, antibiotic resistance has become one of the most …

Importance of efflux pumps in subjugating antibiotic resistance

T Singh, SA Dar, S Das, S Haque - Drug Discovery Targeting Drug …, 2020 - Elsevier
Antibiotic resistance is defined as a condition that assists any disease-causing organism to
resist antibiotics of different class with distinct structure and function directed for its …

New roads leading to old destinations: efflux pumps as targets to reverse multidrug resistance in bacteria

G Spengler, A Kincses, M Gajdács, L Amaral - Molecules, 2017 - mdpi.com
Multidrug resistance (MDR) has appeared in response to selective pressures resulting from
the incorrect use of antibiotics and other antimicrobials. This inappropriate application and …

[HTML][HTML] Suppl 1: Pimozide inhibits the AcrAB-TolC efflux pump in Escherichia coli

JA Bohnert, S Schuster, WV Kern - The open microbiology journal, 2013 - ncbi.nlm.nih.gov
Efflux pump inhibitors (EPIs) are attractive compounds to reverse multidrug-resistance in
clinically relevant bacterial pathogens. In this study we tested the ability of the neuroleptic …

RND Efflux Pump Induction: A Crucial Network Unveiling Adaptive Antibiotic Resistance Mechanisms of Gram-Negative Bacteria

M Novelli, JM Bolla - Antibiotics, 2024 - mdpi.com
The rise of multi-drug-resistant (MDR) pathogenic bacteria presents a grave challenge to
global public health, with antimicrobial resistance ranking as the third leading cause of …

Metabolomics reveal potential natural substrates of AcrB in Escherichia coli and Salmonella enterica Serovar Typhimurium

X Wang-Kan, G Rodríguez-Blanco, AD Southam… - MBio, 2021 - Am Soc Microbiol
In the fight against antibiotic resistance, drugs that target resistance mechanisms in bacteria
can be used to restore the therapeutic effectiveness of antibiotics. The multidrug resistance …

Reserpine is the new addition into the repertoire of AcrB efflux pump inhibitors

A Shaheen, WA Afridi, S Mahboob, M Sana… - Molecular Biology, 2019 - Springer
Acriflavine resistance protein B (AcrB) serves as prototype for multidrug resistance (MDR)
efflux transporters of resistance nodulation division (RND) superfamily. AcrB has been …

Molecular cloning and characterization of SmrA, a novel ABC multidrug efflux pump from Stenotrophomonas maltophilia

A Al-Hamad, M Upton, J Burnie - Journal of antimicrobial …, 2009 - academic.oup.com
Objectives Stenotrophomonas maltophilia is an emerging nosocomial pathogen that can
cause difficult-to-treat infections and exhibits significant degrees of poorly understood …

Phenolic compound ethyl 3, 4-dihydroxybenzoate retards drug efflux and potentiates antibiotic activity

WJ Lu, YJ Huang, HJ Lin, CJ Chang, PH Hsu, GX Ooi… - Antibiotics, 2022 - mdpi.com
The World Health Organization indicated that antibiotic resistance is one of the greatest
threats to health, food security, and development in the world. Drug resistance efflux pumps …