Multidrug efflux pumps are chromosomally encoded genetic elements capable of mediating
resistance to toxic compounds in several life forms. In bacteria, these elements are involved …

Efflux transporters of the RND family confer resistance to multiple antibiotics in Gram-
negative bacteria. Here, we identify and chemically optimize pyridylpiperazine-based …

Bacterial efflux pumps are active transport proteins responsible for resistance to selected
biocides and antibiotics. It has been shown that production of efflux pumps is up-regulated in …

The plasma membrane localization of efflux transporters, such as multidrug resistance‑
associated protein (MRP/ABCC), is governed by scaffold proteins, such as the …

The natural alkaloid berberine has been demonstrated to inhibit the Pseudomonas
aeruginosa multidrug efflux system MexXY-OprM, which is responsible for tobramycin …

Introduction: Microbial resistance against antibiotics is a serious threat to the effective
treatment of infectious diseases. Several mechanisms exist through which microorganisms …

Abstract The AcrAB-TolC MDR efflux system confers intrinsic MDR and overproduction
confers clinically relevant resistance to some antibiotics active against Gram-negative …

Efflux pumps are always at the forefront of bacterial multidrug resistance and account for the
failure of antibiotics. The present study explored the potential of 2-(2-Aminophenyl) indole …

Traditional antimicrobials are increasingly suffering from the emergence of multidrug
resistance among pathogenic microorganisms. To overcome these deficiencies, a range of …

Inhibitors of drug efflux pumps have great potential as pharmacological agents that restore
the drug susceptibility of multidrug resistant bacterial pathogens. Most attention has been …