Inhibitors of drug efflux pumps have great potential as pharmacological agents that restore
the drug susceptibility of multidrug resistant bacterial pathogens. Most attention has been …

Efflux pumps are a relevant factor in antimicrobial resistance. In E. coli, the tripartite efflux
pump AcrAB-TolC removes a chemically diverse set of antibiotics from the bacterium …

With the advent of antibiotics, bacterial infections were supposed to be a thing of past.
However, this instead led to the selection and evolution of bacteria with mechanisms to …

The emergence of active efflux as a major causative factor in antibiotic resistance has been
one of the most significant trends in antiinfective chemotherapy over the last decade. The …

The efflux systems of bacteria protect cells from antibiotics and biocides by actively
transporting compounds out of the cytoplasm and/or periplasm and thereby limit their steady …

The active multidrug efflux pump (EP) has been described as one of the mechanisms
involved in the natural drug resistance of bacteria, such as mycobacteria. As a result, the …

Flavonoids are widely occurring secondary plant constituents, and are abundant in
vegetable and fruit diets as well as herbal medicines. Therapeutic treatment options for …

Efflux pumps are a serious challenge for the development of antibacterial agents.
Overcoming efflux requires an in-depth understanding of efflux pump functions, specificities …

Overexpression of NorA efflux pumps plays a pivotal role in the multidrug-resistance
mechanism in S. aureus. Here, we investigated the activities of prenylated isoflavonoids …

The multidrug efflux system MexXY-OprM, inside the resistance-nodulation-division family, is
a major determinant of aminoglycoside resistance in Pseudomonas aeruginosa. In the fight …