Inflammatory responses play pivotal roles in cancer development, including tumor initiation,
promotion, progression, and metastasis. Cytokines are now recognized as important …

In the last several decades, the number of people dying from cancer-related deaths has not
reduced significantly despite phenomenal advances in the technologies related to diagnosis …

The IL-1 family of cytokines currently comprises of seven ligands with pro-inflammatory
activity (IL-1α and IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL-36γ) as well as two ligands with anti …

Abstract The interleukin-1 (IL-1) family is one of the first described cytokine families and
consists of eight cytokines (IL-1β, IL-1α, IL-18, IL-33, IL-36α, IL-36β, IL-36γ and IL-37) and …

Interleukin-6 (IL-6) is a pleiotropic cytokine that activates a classic signalling pathway upon
binding to its membrane-bound receptor (IL-6R). Alternatively, IL-6 may 'trans-signal'in a …

IL-6 is a critical cytokine in acute phase response and involved in the pathogenesis of
several chronic inflammatory diseases including cancer. Studies have highlighted that levels …

Interleukin-6 (IL-6) is a multifunctional cytokine which plays an important role in a wide
range of biologic activities in different types of cell including tumor cells. IL-6 is involved in …

Abstract Interleukin-6 (IL-6) is a member of the pro-inflammatory cytokine family, induces the
expression of a variety of proteins responsible for acute inflammation, and plays an …

Within the tumor microenvironment, IL-6 signaling is generally considered a malevolent
player, assuming a dark visage that promotes tumor progression. Chronic IL-6 signaling is …

IL-6 signaling plays a prominent role in tumorigenesis and metastasis. In this review we
discuss the recent evidence describing the tumor intrinsic and extrinsic functions of this …