IL-6 and related cytokines as the critical lynchpins between inflammation and cancer
K Taniguchi, M Karin - Seminars in immunology, 2014 - Elsevier
Inflammatory responses play pivotal roles in cancer development, including tumor initiation,
promotion, progression, and metastasis. Cytokines are now recognized as important …
promotion, progression, and metastasis. Cytokines are now recognized as important …
Role of interleukin-6 in cancer progression and therapeutic resistance
In the last several decades, the number of people dying from cancer-related deaths has not
reduced significantly despite phenomenal advances in the technologies related to diagnosis …
reduced significantly despite phenomenal advances in the technologies related to diagnosis …
IL-1 family members in cancer; two sides to every story
The IL-1 family of cytokines currently comprises of seven ligands with pro-inflammatory
activity (IL-1α and IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL-36γ) as well as two ligands with anti …
activity (IL-1α and IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL-36γ) as well as two ligands with anti …
[HTML][HTML] The interleukin-1 cytokine family members: Role in cancer pathogenesis and potential therapeutic applications in cancer immunotherapy
Abstract The interleukin-1 (IL-1) family is one of the first described cytokine families and
consists of eight cytokines (IL-1β, IL-1α, IL-18, IL-33, IL-36α, IL-36β, IL-36γ and IL-37) and …
consists of eight cytokines (IL-1β, IL-1α, IL-18, IL-33, IL-36α, IL-36β, IL-36γ and IL-37) and …
The role of the interleukin (IL)-6/IL-6 receptor axis in cancer
Interleukin-6 (IL-6) is a pleiotropic cytokine that activates a classic signalling pathway upon
binding to its membrane-bound receptor (IL-6R). Alternatively, IL-6 may 'trans-signal'in a …
binding to its membrane-bound receptor (IL-6R). Alternatively, IL-6 may 'trans-signal'in a …
IL-6 family cytokines: Key inflammatory mediators as biomarkers and potential therapeutic targets
N Unver, F McAllister - Cytokine & growth factor reviews, 2018 - Elsevier
IL-6 is a critical cytokine in acute phase response and involved in the pathogenesis of
several chronic inflammatory diseases including cancer. Studies have highlighted that levels …
several chronic inflammatory diseases including cancer. Studies have highlighted that levels …
Interleukin-6 signaling pathway in targeted therapy for cancer
Y Guo, F Xu, TJ Lu, Z Duan, Z Zhang - Cancer treatment reviews, 2012 - Elsevier
Interleukin-6 (IL-6) is a multifunctional cytokine which plays an important role in a wide
range of biologic activities in different types of cell including tumor cells. IL-6 is involved in …
range of biologic activities in different types of cell including tumor cells. IL-6 is involved in …
Interleukin-6: a masterplayer in the cytokine network
P Uciechowski, W Dempke - Oncology, 2020 - karger.com
Abstract Interleukin-6 (IL-6) is a member of the pro-inflammatory cytokine family, induces the
expression of a variety of proteins responsible for acute inflammation, and plays an …
expression of a variety of proteins responsible for acute inflammation, and plays an …
The two faces of IL-6 in the tumor microenvironment
DT Fisher, MM Appenheimer, SS Evans - Seminars in immunology, 2014 - Elsevier
Within the tumor microenvironment, IL-6 signaling is generally considered a malevolent
player, assuming a dark visage that promotes tumor progression. Chronic IL-6 signaling is …
player, assuming a dark visage that promotes tumor progression. Chronic IL-6 signaling is …
The IL-6 feed-forward loop: a driver of tumorigenesis
Q Chang, L Daly, J Bromberg - Seminars in immunology, 2014 - Elsevier
IL-6 signaling plays a prominent role in tumorigenesis and metastasis. In this review we
discuss the recent evidence describing the tumor intrinsic and extrinsic functions of this …
discuss the recent evidence describing the tumor intrinsic and extrinsic functions of this …