Autoantibodies against astrocyte water channel aquaporin-4 (AQP4) are highly specific for
neuromyelitis optica (NMO). However, the molecular mechanism of NMO still remains …

Background: Neuromyelitis optica (NMO) is a disease of the CNS characterized by severe
optic neuritis and longitudinally extended transverse myelitis. Recent studies suggest that …

Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous
system (CNS). Anti-aquaporin-4 antibody (AQP4-Ab) is a highly specific serum autoantibody …

Neuromyelitis optica (NMO) is a rare CNS inflammatory disorder that predominantly affects
the optic nerves and spinal cord. Recent serological findings strongly suggest that NMO is a …

Neuromyelitis optica (NMO)-immunoglobulin G (IgG) is a clinically validated serum
biomarker that distinguishes relapsing central nervous system (CNS) inflammatory …

In neuromyelitis optica (NMO), B-cell autoimmunity to aquaporin-4 (AQP4) has been shown
to be essential. However, the role of T cells remains ambiguous. Here, we first showed an …

The autoantibody to aquaporin-4 (AQP4) is a marker and a pathogenetic factor in
Neuromyelitis Optica (NMO)(Devic's syndrome). Our aim was to identify B-cell antigenic …

Neuromyelitis optica spectrum disorders (NMOSD) are associated with anti-aquaporin-4
autoantibodies (AQP4-IgG). Limited data is available on longitudinal cerebrospinal fluid …

Background Antibodies to the water channel protein aquaporin-4 (AQP4), which is
expressed in astrocytic endfeet at the blood brain barrier, have been identified in the serum …

Introduction Neuromyelitis optica spectrum disorder (NMOSD) is characterized by the
presence of serum anti-aquaporin 4 (AQP4) antibody. However, the significance of changes …