Objectives: The aim of this study was to investigate the effects of angiotensin II (Ang II) on
fibroblast proliferation and endothelin-1 (ET-1) gene induction, focusing especially on …

Abstract Objective: Angiotensin II (Ang II) increases vascular endothelin-1 (ET-1) tissue
levels, which in turn mediate a major part of Ang II-stimulated vascular growth and …

Background: Circulating angiotensin II (Ang II) increases vascular endothelin-1 (ET-1) tissue
levels, which in turn mediate a major part of Ang II-stimulated vascular growth and …

Objective: To examine whether 17-β-oestradiol (E2) may alter angiotensin II (Ang II) induced
cell proliferation and to identify the putative underlying signalling pathways in rat cardiac …

Endothelin-1 (ET-1) has been implicated in fibroblast proliferation. However, the mechanism
involving ET-1 is not clear. The present study was performed to examine the role of …

L. Piacentini, M. Gray, NY Honbo, J. Chentoufi, M. Bergman and JS Karliner. Endothelin-1
Stimulates Cardiac Fibroblast Proliferation Through Activation of Protein Kinase C. Journal …

It is well documented that 17β-estradiol (E2) exerts a cardiovascular protective effect. A
possible role of E2 in the regulation of endothelin-1 (ET-1) production has been reported …

AIMS: Hypertensive patients develop cardiac hypertrophy and fibrosis with increased
stiffness, contractile deficit and altered perfusion. Angiotensin II (AngII) is an important factor …

Objectives: Recent evidence indicates that reactive oxygen species (ROS) may act as
second messengers in receptor-mediated signaling pathways. The possible role of ROS …

Endothelin-1 (Et-1) is a peptide synthesized by endothelial cells (ECs) both in culture and in
vivo. Cyclic strain induces gene expression of Et-1, however, the molecular mechanisms …