Osteopontin (OPN) has been identified as the most prominent cytokine-encoding gene
expressed within multiple sclerosis (MS) lesions. Recently, we demonstrated that OPN …

In the search for proteins that might play a role in the pathogenesis of multiple sclerosis
(MS), osteopontin (OPN) has been identified as the most prominent cytokine‐encoding gene …

Osteopontin (OPN) is a pleiotropic integrin binding protein with functions in cell-mediated
immunity, inflammation, tissue repair, and cell survival. Recent studies have shown that OPN …

Osteopontin (OPN) up-regulates pro-inflammatory cytokines from both T helper type 1 and T
helper type 17 cell pathways. We measured plasma OPN levels in Japanese multiple …

Background: Osteopontin (OPN) is a pleiotropic protein with important roles in inflammation
and immunity that has been suggested as a candidate biomarker for disease activity in …

Background: The cytokine osteopontin (OPN) is a potential key player in the
immunopathogenesis of multiple sclerosis (MS) and a candidate biomarker for disease …

The pro-inflammatory cytokine osteopontin has been found to be highly expressed in
multiple sclerosis lesions and plasma levels are increased during relapses in relapse-onset …

Osteopontin (OPN) is an inflammatory cytokine highly expressed in multiple sclerosis (MS)
plaques. In a previous work, we showed that four OPN polymorphisms form three haplotypes …

Osteopontin (OPN) is a proinflammatory marker produced by systemic immune and central
nervous system (CNS) resident cells. We examined, if the level of OPN in the cerebrospinal …

Osteopontin is a proinflammatory molecule, modulating TH1 and TH17 responses. Several
reports suggest its involvement in multiple sclerosis (MS) pathogenesis. We previously …