Identifying a reliable biomarker may accelerate diagnosis of multiple sclerosis (MS) and lead
to early management of the disease. Accumulating evidence suggest that cerebrospinal fluid …

Osteopontin (OPN) was suggested to have a role in the pathophysiology of MS and in bone
metabolism. However, we formerly reported increased presence of osteoporosis in MS …

Objective To determine cerebrospinal fluid levels of osteopontin (OPN), a proinflammatory
cytokine that was found to be overexpressed in multiple sclerosis lesions and increased in …

Osteopontin (OPN) is highly expressed in demyelinating lesions in multiple sclerosis (MS)
and experimental autoimmune encephalomyelitis (EAE). OPN is cleaved by thrombin into N …

Background Despite recent advances in therapy that have improved the overall disease
course in multiple sclerosis (MS), the prognosis at the outset remains unpredictable …

Osteopontin (OPN) is a key immunoregulator in the autoimmune-mediated demyelinating
disease multiple sclerosis. OPN may also play a role in the remyelination since it is 1) a …

Osteopontin (OPN) is an extracellular matrix protein with chemokine, cytokine and integrin
properties. It has multiple immunological functions and is secreted by activated …

Osteopontin (OPN) exhibits pleiotropic functions and abundant transcripts for OPN are
present in brains of patients with multiple sclerosis (MS). The aim of this study was to …

Biomarkers capable of predicting the clinical course and the rate of disease progression in
multiple sclerosis are currently unavailable. Our objective was to examine if the levels of …

A role for osteopontin (OPN) in promoting disease activity of multiple sclerosis or its animal
model experimental autoimmune encephalomyelitis (EAE) has recently been suggested. As …