New treatment options for patients with advanced neuroendocrine tumors

JA Chan, MH Kulke - Current treatment options in oncology, 2011 - Springer
Opinion statement Well-to moderately differentiated neuroendocrine tumors (NET) are a
heterogeneous group of malignancies for which a range of therapeutic options have been …

Systemic therapy for advanced pancreatic neuroendocrine tumors

MH Kulke - Seminars in oncology, 2013 - Elsevier
Neuroendocrine tumors (NETs) occur throughout the body, and share similar histologic
characteristics. However, it has become increasingly evident that pancreatic NETs tend to …

Systemic therapy for advanced pancreatic neuroendocrine tumors: an update

DL Reidy-Lagunes - Journal of the National Comprehensive Cancer …, 2012 - jnccn.org
Well-differentiated neuroendocrine tumors (NETs) can be subdivided into carcinoid and
pancreatic NETs (pancNETs). Although these tumors share many morphologic and clinical …

Evolving diagnostic and treatment strategies for pancreatic neuroendocrine tumors

MH Kulke, J Bendell, L Kvols, J Picus… - Journal of hematology & …, 2011 - Springer
Pancreatic neuroendocrine tumors (NET) have diverse clinical presentations. Patients with
symptoms of hormone secretion may require specific medical interventions to control those …

Multicenter phase II trial of temsirolimus and bevacizumab in pancreatic neuroendocrine tumors

TJ Hobday, R Qin, D Reidy-Lagunes… - Journal of Clinical …, 2015 - ascopubs.org
Purpose There are few effective therapies for pancreatic neuroendocrine tumors (PNETs).
Recent placebo-controlled phase III trials of the mammalian target of rapamycin (mTOR) …

Expert consensus for the management of advanced or metastatic pancreatic neuroendocrine and carcinoid tumors

D Castellano, E Grande, J Valle, J Capdevila… - Cancer Chemotherapy …, 2015 - Springer
Neuroendocrine tumors (NETs) are rare tumors that have been increasing in incidence over
the last 30 years with no significant changes in survival. As survival of patients with these …

Pancreatic neuroendocrine tumors: entering a new era

PE Oberstein, H Remotti, MW Saif… - JOP. Journal of the …, 2012 - serena.unina.it
Neuroendocrine tumors (NETs) describe a heterogeneous group of tumors with a wide
range of morphologic, functional, and behavioral characteristics. These tumors are generally …

Novel therapeutic agents for the treatment of gastroenteropancreatic neuroendocrine tumors

ME Pavel, B Wiedenmann - Hormone and metabolic research, 2011 - thieme-connect.com
Neuroendocrine tumors (NET) are frequently diagnosed late and not amenable to curative
surgery due to metastatic disease to the liver and lymph nodes. The disease is complex and …

Advances in the systemic treatment of neuroendocrine tumors in the era of molecular therapy

R Leung, B Lang, H Wong, J Chiu… - Anti-Cancer Agents …, 2013 - ingentaconnect.com
Neuroendocrine tumors (NETs) are heterogeneous in underlying tumor biology and clinical
presentations. They are generally classified according to their degree of differentiation and …

Therapy innovations: tyrosine kinase inhibitors for the treatment of pancreatic neuroendocrine tumors

E Raymond, T Hobday, D Castellano… - Cancer and Metastasis …, 2011 - Springer
Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) show limited sensitivity to
cytotoxic agents, requiring the search for novel therapies. Recently, data from a phase III trial …