The transition from acute to chronic musculoskeletal pain is not well understood. To
understand this transition, it is important to know how peripheral and central sensitization …

The aim of this Review is to give a short presentation of the manifestations, assessment
methods, and mechanisms underlying localized and widespread musculoskeletal pain …

Diagnosis and management of musculoskeletal pain is a major clinical challenge.
Fundamental knowledge of nociception from deep somatic structures and related …

This report provides a brief introduction to the manifestations of peripheral and central
sensitization involved in musculoskeletal pain disorders. It has become increasingly evident …

Until recently, most clinicians considered chronic pain to be typically due to ongoing
peripheral nociceptive input (ie, damage or inflammation) in the region of the body where …

Objectives: Improvements in pain management might be achieved by matching treatment to
underlying mechanisms for pain persistence. Many authors argue for a mechanism-based …

The past few decades have witnessed a huge leap forward in our understanding of the
mechanistic underpinnings of pain, in normal states where it helps protect from injury, and …

Mechanism-based classification of pain has been advocated widely to aid tailoring of
interventions for individuals experiencing persistent musculoskeletal pain. Three pain …

Muscle pain can be induced and assessed experimentally by a variety of methods. Ischemic
and exercise-induced muscle pain are typical endogenous pain models; external stimulation …

In the past three decades, a scientific revolution has occurred in the understanding of the
experience of pain. However, a clinical revolution based on the new science is yet to occur …