To detect quinolone resistance-associated mutations within the Ser-80 and Glu-84 codons
of the Pseudomonas aeruginosa parC gene, we developed a rapid and simple assay based …

Principal mechanisms of bacterial resistance to quinolones are modification of target
enzymes, DNA gyrase (gyrA) and topoisomerase IV (parC), or reduction of intracellular …

Pseudomonas aeruginosa is a leading pathogen that has become increasingly resistant to
the fluoroquinolone antibiotics due to widespread prescribing. Adverse outcomes have been …

In this study, we examined mutations in the quinolone resistance-determining regions
(QRDRs) of the gyrA and parC genes of Pseudomonas aeruginosa (P. aeruginosa) clinical …

Mutations in the quinolone resistance-determining regions (QRDRs) of gyrA, gyrB, parC,
and parE have been characterized among the 232 isolates of ciprofloxacin (CIP)-resistant …

Materials and Methods Quinolone-resistant clinical strains of P. aeruginosa (n= 20) and E.
faecium (n= 12) were used. P. aeruginosa PAO1, E. faecium ATCC19434 and one …

The aim of this study was to examine mutations in the quinolone-resistance-determining
region (QRDR) of gyrA and parC genes in Pseudomonas aeruginosa isolates. A total of 100 …

We determined partial sequences of the gyrA and parC genes of the fluoroquinolone-
susceptible strain ATCC 27853 and 22 clinical isolates of Pseudomonas aeruginosa. While …

Objectives: Quinolone resistance in the opportunistic pathogen Pseudomonas aeruginosa is
commonly caused by mutations that alter the target molecules DNA gyrase/topoisomerase …

Pseudomonas aeruginosa which is widely found in the environment, may lead to serious
nosocomial infections. Due to its intrinsic resistance to many antibacterial agents, treatment …