BACKGROUND.: The results of clinical trials of xanthine oxidoreductase inhibition in cardiac
surgery are encouraging, although studies have failed to localize the enzyme to the human …

Experiments were performed to determine if xanthine oxidase is a source of free radicals
during myocardial ischemia. Open chest dogs were subjected to 1 h of total occlusion of the …

Xanthine oxidase is responsible for the release of free oxygen radicalsduring myocardial
reperfusion. Allopurinol was shown to be an effectiveinhibitor of this reaction in the …

Objective: Cardiac injury, related to ischaemia and reperfusion, may be caused by the action
of oxygen free radicals. Xanthine oxidoreductase activity may be an important free radical …

Oxygen-derived free radicals are known to take part in cardiac injury during post-ischemic
reperfusion (I/R). Xanthine oxidase (XO) is closely associated with the generation of …

The enzyme, xanthine oxidase, has become a focus of research activity because of its
proposed role as a source of destructive free radicals in ischaemia reperfusion injury [l]. The …

Cardiopulmonary and other organ dysfunction often occurs after operation on the
descending thoracic aorta. Though there are multiple causes of organ dysfunction in this …

It is currently believed that reactive oxygen species are produced in the heart post-ischemia-
reperfusion, causing pathophysiological disorders. Studies reported in the literature dealing …

The xanthine oxidase pathway has been proposed as a source ofoxygen-derived free
radicals in ischemic and reperfused myocardium. A spectrophotometric assay was …

Xanthine oxidase is the pathological form of xanthine oxidoreductase, which generates free
oxygen radicals, when it converts (hypo) xanthine to urate. We studied 1. developmental …