The development of immune checkpoint blockade (ICB) therapies has been instrumental in
advancing the field of immunotherapy. Despite the prominence of these treatments, many …

The metabolic reprogramming of tumor cells and immune escape are two major hallmarks of
cancer cells. The metabolic changes that occur during tumorigenesis, enabling survival and …

With the rapid rise of immunotherapy for cancer treatment, attention has focused on gaining
a better understanding of T-cell biology in the tumor microenvironment. Elucidating the …

T cells are an important component of adaptive immunity and protect the host from infectious
diseases and cancers. However, uncontrolled T cell immunity may cause autoimmune …

Metabolic reprogramming of cancer cells and the tumor microenvironment are emerging as
key factors governing tumor growth, metastasis, and response to therapies including …

Highlights•Metabolic stress in tumors impairs T cell anti-tumor immunity.•Memory T cells
could be optimal cell type to sustain metabolic fitness in tumors.•Skewing memory T cell …

It is notorious that cancer cells alter their metabolism to adjust to harsh environments of
hypoxia and nutritional starvation. Metabolic reprogramming most often occurs in the tumor …

Tumor cells reprogram nutrient acquisition and metabolic pathways to meet their energetic,
biosynthetic, and redox demands. Similarly, metabolic processes in immune cells support …

Conversion of normal cells to cancer is accompanied with changes in their metabolism.
During this conversion, cell metabolism undergoes a shift from oxidative phosphorylation to …

Mounting evidence has revealed that the therapeutic efficacy of immunotherapies is
restricted to a small portion of cancer patients. A deeper understanding of how metabolic …