The immune system and metabolism are highly integrated and multilevel interactions
between metabolic system and T lymphocyte signaling and fate exist. Accumulating …

Metabolism drives function, on both an organismal and a cellular level. In T cell biology,
metabolic remodeling is intrinsically linked to cellular development, activation, function …

Immune checkpoint inhibitors (ICIs) targeting immune checkpoint proteins, such as CTLA-4
and PD-1/PD-L1, have demonstrated remarkable and durable clinical responses in various …

The cancer-immunity cycle (CIC) comprises a series of events that are required for immune-
mediated control of tumor growth. Interruption of one or more steps of the CIC enables …

Cancer immunotherapy is an increasingly successful strategy for the treatment of patients
who have advanced or conventional therapy-resistant cancers. T cells are key mediators of …

ABSTRACT Vitamin B5 (panthotenic acid), the precursor of coenzyme A (CoA), is contained
in most food items and is produced by the intestinal microbiota. A recent study published in …

Innate and adaptive immune cells from myeloid and lymphoid lineages resolve host
infection or cell stress by mounting an appropriate and durable immune response. Upon …

How tumor-infiltrating T lymphocytes (TILs) adapt to the metabolic constrains within the
tumor microenvironment (TME) and to what degree this affects their ability to combat tumor …

Metabolic and signaling pathways are integrated to determine T cell fate and function. As
stimulated T cells gain distinct effector functions, specific metabolic programs and demands …

Besides transformed cells, the tumors are composed of various cell types that contribute to
undesirable tumor progression. Tumor‐associated macrophages (TAMs) are the most …