Background: The developmental transcription factor Grainyhead-like 3 (GRHL3) plays a
critical tumor suppressor role in the mammalian epidermis through direct regulation of PTEN …

Abstract Grainyhead-Like 2 (GRHL2) is an epithelial-specific transcription factor that
regulates epithelial morphogenesis and differentiation. Prior studies suggested inverse …

Despite its prevalence, the molecular basis of squamous cell carcinoma (SCC) remains
poorly understood. Here, we identify the developmental transcription factor Grhl3 as a potent …

Abstract Grainyhead-like 2 (GRHL2) is one of the three mammalian homologues of
Drosophila Grainyhead involved in epithelial morphogenesis. We recently showed that …

We recently identified Grainyhead-like 2 (GRHL2), a mammalian homolog of Grainyhead in
Drosophila, to be a novel transcription factor that regulates hTERT gene expression and …

The transcription factor grainyhead‐like 2 (GRHL2) plays a crucial role in various
developmental processes. Although GRHL2 recently has attracted considerable interest in …

The Grainyhead-like 1 (GRHL1) transcription factor regulates the expression of desmosomal
cadherin desmoglein 1 (Dsg1) in suprabasal layers of the epidermis. As a consequence, the …

Background & Aims Esophageal squamous cell carcinoma (ESCC) is an aggressive
malignancy with a poor long-term prognosis. The molecular mechanisms underlying the …

The transcription factor grainyhead-like 2 (GRHL2) is evolutionarily conserved in many
different species, and is involved in morphogenesis, epithelial differentiation, and the control …

Abstract Background The Grainyhead-like (GRHL) transcription factors have been linked to
many different types of cancer. However, no previous study has attempted to investigate …