Activation of NLRP3 inflammasomes is crucial in the pathological process of Ulcerative
colitis (UC), which could be negatively regulated by PINK1/Parkin-driven mitophagy …

In the present study, the effect of asiatic acid, a natural triterpenoid compound, on murine
experimental colitis induced by dextran sulfate sodium (DSS) and its possible mechanism …

NLRP3 inflammasome has been reported to be associated with inflammatory bowel disease
including colitis due to its potential ability to induce IL-1β secretion. Emerging studies have …

Previous studies reported that Ginsenoside Rd (Rd) had anti-inflammatory and anti-cancer
effects. However, the molecular mechanism underlying the inhibition effect of Rd on colitis in …

Background: Ulcerative colitis (UC) is a chronic recurrent inflammatory bowel disease (IBD).
The conventional drugs for UC may induce severe side effects. Herbal medicine is …

Inflammatory bowel diseases (IBDs) are increasingly common diseases characterized by
chronic and relapsing inflammation of the gastrointestinal tract. NLRP3 might be a crucial …

Emerging evidence suggests that NLRP3 inflammasome was associated with various kinds
of immunological diseases including colitis. However, there are few drugs targeting …

NLRP3 inflammasome has been reported to be associated with various kinds of
immunological diseases including colitis. However, there are few drug candidates targeting …

Background NLRP3 inflammasome mediates IL-1β maturation, therefore plays a vital role in
the development of IBD. Curcumin is known for possessing strong anti-inflammatory …

In the present study, we examined the effects of dimethyl fumarate (DMF) on dextran sulfate
sodium (DSS)-induced murine colitis, an animal model which mimics human IBD. Oral …