The neurotransmitter serotonin (5-HT) plays an important role in both the peripheral and
central nervous systems. The biosynthesis of serotonin is regulated by two rate-limiting …

Serotonin synthesis in mammals is initiated by 2 distinct tryptophan hydroxylases (TPH),
TPH1 and TPH2. By genetically ablating TPH2, we created mice (Tph2−/−) that lack …

Probably the foremost hypothesis of depression is the 5-hydroxytryptamine (5-HT, serotonin)
deficiency hypothesis. Accordingly, anomalies in putative 5-HT biomarkers have repeatedly …

Tryptophan hydroxylase (TPH) is a rate limiting enzyme in the synthesis of serotonin (5-HT),
a monoamine which works as an autacoid in the periphery and as a neurotransmitter in the …

Dysregulation of tryptophan hydroxylase (TPH)-dependent serotonin (5-HT) synthesis, has
been implicated in various neuropsychiatric disorders, although the differential expression …

Reductions in function within the serotonin (5HT) neuronal system have long been proposed
as etiological factors in depression. Selective serotonin reuptake inhibitors (SSRIs) are the …

Serotonin [5-hydroxytryptamine (5-HT)] is a major therapeutic target of psychiatric disorders.
Tryptophan hydroxylase (TPH) catalyzes the rate-limiting reaction in the biosynthesis of 5 …

Brain serotonin (5-HT) neurotransmission plays a key role in the regulation of mood and has
been implicated in a variety of neuropsychiatric conditions. Tryptophan hydroxylase (TPH) is …

Serotonin (5-hydroxytryptophan, 5-HT) is a neurotransmitter synthesized in the raphe nuclei
of the brain stem and involved in the central control of food intake, sleep, and mood …

Abstract Serotonin (5-hydroxytriptamine; 5-HT) is a fascinating neurotransmitter that thanks
to an extensive axonal network is released throughout the entire central nervous system …