Immunoglobulin A (IgA) glycosylation, recognized as an important pathogenic factor in IgA
nephropathy (IgAN), is apparently controlled by the polarity of T helper (Th) cytokine …

Studies were undertaken to elucidate the primary pathogenetic mechanisms responsible for
immunoglobulin (Ig) A immune complexes formation and glomerular deposition in vivo …

The hypothesis that abnormalities of immune function might occur in healthy first degree
relatives of two patients with a familial IgA nephropathy was tested. After 7 days of culture …

In the last few years the mucosal origin of the IgA deposited in the kidneys of patients with
IgA nephropathy has been examined by several investigators. We have previously …

Recent reports of recurrence of the IgA nephropathy (IgAN) in transplanted kidneys [1] and
cutaneous deposition of IgA in patients with IgAN [2] tend to suggest that IgAN is a systemic …

Complement activation in experimental IgA nephropathy: An antigen mediated process.
Complement activation associated with immune complex glomerular deposition plays an …

We examined complement control proteins focusing on the role of modulating the
complement activation in IgA nephropathy. Glomerular C4-binding protein (C4-bp) deposits …

We utilized a model of experimental interstitial nephritis induced by renal tubular antigen in
complete Freund's adjuvant to examine a mechanism of immunologic tolerance produced by …

Based on a hint from an immunological abnormality found in human IgA nephropathy, we
tried to make up an experimental IgA nephropathy in mice by administration of a food …

We hypothesized that the altered immunoglobulin synthesis and/or lymphocyte function
apparent in patients with IgA nephropathy might be, at least partially, genetically determined …