Polysubstituted pyrrolidines linked to 1, 2, 3-triazoles: Synthesis, crystal structure, DFT studies, acid dissociation constant, drug-likeness, and anti-proliferative activity
Abstract Novel pyrrolidines linked to 1, 2, 3-triazole derivatives, dimethyl 1-(2-(4-R-1 H-1, 2,
3-triazol-1-yl) acetyl)-5, 5-diphenylpyrrolidine-2, 4-dicarboxylate, were synthesized in the …
3-triazol-1-yl) acetyl)-5, 5-diphenylpyrrolidine-2, 4-dicarboxylate, were synthesized in the …
[HTML][HTML] Synthesis of functionalized aminopyrazole and pyrazolopyrimidine derivatives: Molecular modeling and docking as anticancer agents
Three new functionalized 4-aminopyrazole derivatives were synthesized and cyclized with
phenyl isothiocyanate to yield the corresponding three pyrazolo [4, 3-d] pyrimidine …
phenyl isothiocyanate to yield the corresponding three pyrazolo [4, 3-d] pyrimidine …
[HTML][HTML] Synthesis, molecular modeling and bioactivity of new bis-thiazole, thiazole-pyrazole, and thiazole-pyridine analogues
A Bayazeed, RB Alnoman, K Alatawi… - Journal of Saudi …, 2023 - Elsevier
Several new thiazole derivatives linked pyrazole and/or pyridine rings were synthesized
based on the versatile precursor 2-(5-acetyl-4-methyl-3-phenylthiazol-2 (3H)-ylidene) …
based on the versatile precursor 2-(5-acetyl-4-methyl-3-phenylthiazol-2 (3H)-ylidene) …
Crystal structure, DFT, antimicrobial, anticancer and molecular docking of (4E)-4-((aryl) methyleneamino)-1, 2-dihydro-2, 3-dimethyl-1-phenylpyrazol-5-one
Abstract The Schiff bases (4 E)-4-((aryl) methyleneamino)-1, 2-dihydro-2, 3-dimethyl-1-
phenylpyrazol-5-one 3 were synthetized by reaction of aromatic aldehydes 1 and 4 …
phenylpyrazol-5-one 3 were synthetized by reaction of aromatic aldehydes 1 and 4 …
Synthesis, characterization, X-Ray crystal study and bioctivities of pyrazole derivatives: Identification of antitumor, antifungal and antibacterial pharmacophore sites
The reaction of hydroxymethyl pyrazole derivatives with one equivalent of the appropriate
primary amine yields N-((1h-pyrazol-1-yl) methyl) pyrimidin-2-amine (L 1), 2-(((1h-pyrazol-1 …
primary amine yields N-((1h-pyrazol-1-yl) methyl) pyrimidin-2-amine (L 1), 2-(((1h-pyrazol-1 …
Design, synthesis, anticancer activity of new amide derivatives derived from 1, 2, 3-triazole-benzofuran hybrids: An insights from molecular docking, molecular …
N Gariganti, SK Loke, E Pagadala, P Chinta… - Journal of Molecular …, 2023 - Elsevier
A new series of amide derivatives derived from 1, 2, 3-triazole-benzofuran hybrids (9a-j)
have been synthesized and their structures were confirmed by using spectroscopic …
have been synthesized and their structures were confirmed by using spectroscopic …
A new synthesis of poly heterocyclic compounds containing [1, 2, 4] triazolo and [1, 2, 3, 4] tetrazolo moieties and their DFT study as expected anti-cancer reagents
EM Abdelrehim, DS El-Sayed - Current Organic Synthesis, 2020 - ingentaconnect.com
Background: 2-amino-3-cyanopyridines are good starting reagents that have been used in
synthesis of many heterocyclic compounds such as pyridopyrimidines,[1, 2, 4] triazolo and …
synthesis of many heterocyclic compounds such as pyridopyrimidines,[1, 2, 4] triazolo and …
Design and synthesis of novel 2-(4-(2-(dimethylamino) ethyl)-4H-1, 2, 4-triazol-3-yl) pyridines as potential antitumor agents
M Qin, X Zhai, H Xie, J Ma, K Lu, Y Wang… - European Journal of …, 2014 - Elsevier
Abstract New 2-(4-(2-(dimethylamino) ethyl)-4H-1, 2, 4-triazol-3-yl) pyridine derivatives were
synthesized and evaluated for their in vitro cytotoxicity against five cancer cell lines namely …
synthesized and evaluated for their in vitro cytotoxicity against five cancer cell lines namely …
Synthesis, anti-proliferative activity, gene expression, docking and DFT investigation of novel pyrazol-1-yl-thiazol-4 (5H)-one derivatives
In this elucidation, the novel thaizolone derivatives 8a-n were synthesised via the reaction
between thioamide derivatives 4a, b with chloroacetic acid and the appropriate aldehyde …
between thioamide derivatives 4a, b with chloroacetic acid and the appropriate aldehyde …
Synthesis, biological evaluation and DFT calculation of novel pyrazole and pyrimidine derivatives
The utility of the enaminonitriles 3a and 3b for the synthesis of the pyrazole derivatives 5a, b,
7a, b, diaminopyrimidine derivatives 9, 11, pyrazolo [1, 5-a] pyrimidines 12, 15, triazolo [4, 3 …
7a, b, diaminopyrimidine derivatives 9, 11, pyrazolo [1, 5-a] pyrimidines 12, 15, triazolo [4, 3 …