Males and females may respond differently to medications, yet knowledge about sexual
dimorphisms in the effects of polypharmacy remains limited, particularly in aging. This study …

We aimed to develop a mouse model of polypharmacy, primarily to establish whether short-
term exposure to polypharmacy causes adverse geriatric outcomes. We also investigated …

The potential harmful effects of polypharmacy (concurrent use of 5 or more drugs) are
difficult to investigate in an experimental design in humans. Moreover, there is a lack of …

Aging, polypharmacy (concurrent use of≥ 5 medications), and functional impairment are
global healthcare challenges. However, knowledge of the age/sex-specific effects of …

Polypharmacy (use of≥ 5 medications) and increasing Drug Burden Index (DBI) score
(measure of person's total exposure to anticholinergic/sedative medications) are associated …

A major challenge in health care is the lack of knowledge about effects of multiple drug
treatment—polypharmacy—in old age. Randomized clinical trials typically exclude patients …

Polypharmacy (use of≥ 5 drugs) is common in older people but has minimal preclinical or
clinical evidence of safety or efficacy and is associated with adverse outcomes in older …

A major challenge in the health care system is the lack of knowledge about the possible
harmful effects of multiple drug treatments in old age. The present study aims to characterize …

Aging and multimorbidity are associated with inflammation. Polypharmacy is common in
older people with multimorbidity. Given the potential for interactions between polypharmacy …

Functional independence is an important aspect of successful aging and differs with age
and by sex in humans. Physical performance often declines earlier than other age …