Hesperetin ameliorates hepatic oxidative stress and inflammation via the PI3K/AKT-Nrf2-ARE pathway in oleic acid-induced HepG2 cells and a rat model of high-fat …

J Li, T Wang, P Liu, F Yang, X Wang, W Zheng… - Food & function, 2021 - pubs.rsc.org
Non-alcoholic fatty liver disease (NAFLD) is considered the most common liver disease.
Dietary supplementation has become a promising strategy for managing NAFLD …

Apigenin ameliorates HFD-induced NAFLD through regulation of the XO/NLRP3 pathways

Y Lv, X Gao, Y Luo, W Fan, T Shen, C Ding… - The Journal of nutritional …, 2019 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of liver-related
morbidity and mortality disease in the world. However, no effective pharmacological …

Hesperidin attenuates hepatic lipid accumulation in mice fed high-fat diet and oleic acid induced HepG2 via AMPK activation

H Chen, T Nie, P Zhang, J Ma, A Shan - Life Sciences, 2022 - Elsevier
Aims In recent years, more and more people are suffering from lifestyle-related disease such
as nonalcoholic fatty liver disease (NAFLD) because of unhealthy diet and lack of physical …

Erythritol improves nonalcoholic fatty liver disease by activating Nrf2 antioxidant capacity

M Jin, Y Wei, H Yu, X Ma, S Yan, L Zhao… - Journal of Agricultural …, 2021 - ACS Publications
Nonalcoholic fatty liver disease (NAFLD) is a kind of serious fat disorder that has become a
critical problem to human society. Therefore, finding drugs that are safe and effective has …

Resveratrol supplement inhibited the NF-κB inflammation pathway through activating AMPKα-SIRT1 pathway in mice with fatty liver

Y Tian, J Ma, W Wang, L Zhang, J Xu, K Wang… - Molecular and cellular …, 2016 - Springer
Nonalcoholic fatty liver disease (NAFLD) is characterized by high levels of nonesterified fatty
acids (NEFA), inflammation, and hepatic steatosis. Inflammation plays a crucial role in the …

Apigenin, a modulator of PPARγ, attenuates HFD-induced NAFLD by regulating hepatocyte lipid metabolism and oxidative stress via Nrf2 activation

X Feng, W Yu, X Li, F Zhou, W Zhang, Q Shen… - Biochemical …, 2017 - Elsevier
Lipid metabolic disorders and oxidative stress in the liver are key steps in the progression of
nonalcoholic fatty liver disease (NAFLD), which is a major risk factor for the development of …

A narrative review on the role of hesperidin on metabolic parameters, liver enzymes, and inflammatory markers in nonalcoholic fatty liver disease

N Morshedzadeh, A Ramezani Ahmadi… - Food Science & …, 2023 - Wiley Online Library
Insulin resistance, oxidative stress, hyperlipidemia, and inflammation play main roles in the
development of nonalcoholic fatty liver disease (NAFLD). Some studies have reported that …

Green tea extract provides extensive Nrf2‐independent protection against lipid accumulation and NFκB pro‐inflammatory responses during nonalcoholic …

J Li, TN Sapper, E Mah, S Rudraiah… - Molecular nutrition & …, 2016 - Wiley Online Library
Scope Green tea extract (GTE) reduces liver steatosis and inflammation during nonalcoholic
steatohepatitis (NASH). We hypothesized GTE would mitigate NASH in a nuclear factor …

Naringenin attenuates non‐alcoholic fatty liver disease by down‐regulating the NLRP3/NF‐κB pathway in mice

Q Wang, Y Ou, G Hu, C Wen, S Yue… - British Journal of …, 2020 - Wiley Online Library
Background and Purpose Naringenin, a flavonoid compound with strong anti‐inflammatory
activity, attenuated non‐alcoholic fatty liver disease (NAFLD) induced by a methionine …

Quercetin ameliorates nonalcoholic fatty liver disease (NAFLD) via the promotion of AMPK-mediated hepatic mitophagy

P Cao, Y Wang, C Zhang, MA Sullivan, W Chen… - The Journal of nutritional …, 2023 - Elsevier
The global incidence of nonalcoholic fatty liver disease (NAFLD) has been surging in recent
years, however, no drug is currently approved to treat this disease. Quercetin, a natural …