Genome-wide scans for linkage of chromosome regions to type 1 diabetes in affected sib
pair families have revealed that the major susceptibility locus resides within the major …

betes) havealso beenexaminedinthe searchfortypeIIdiabetessusceptibility genes. Althoughvariantshavebeenidentifiedinmany…
, onlyafewhavebeen showntoassociate withdiabetesorimpaired proteinfunction (Fig. 1) …

Insulin-dependent diabetes mellitus (IDDM) is a multigenic autoimmune disease. An IDDM
susceptibility gene was mapped to chromosome 2q34. This gene may act early in …

Type 2 diabetes mellitus is a complex disorder encompassing multiple metabolic defects.
We report results from an autosomal genome scan for type 2 diabetes–related quantitative …

Recent studies have demonstrated that a locus at 11p15, 5 confers susceptibility to insulin
dependent diabetes mellitus (IDDM). This locus has been shown to lie within a 19 kb region …

Type 1 diabetes (T1D) is a genetically complex disorder of glucose homeostasis that results
from the autoimmune destruction of the insulin-secreting cells of the pancreas. Two previous …

Genetic susceptibility to insulin–dependent diabetes mellitus (IDDM) is inherited as a
polygenic trait. One of the loci implicated in IDDM is a polymorphic minisatellite 5′ of the …

Affected-sib-pair analyses were performed using 104 Caucasian families to map genes that
predispose to insulin-dependent diabetes mellitus (IDDM). We have obtained linkage …

The gene region on chromosome 11p15. 5 known to be involved in insulin-dependent
diabetes mellitus (IDDM) susceptibility was recently mapped to a 4.1-kilobase region …

Family and twin studies have shown clearly that Type I (insulin-dependent) diabetes mellitus
has a genetic basis. However, only within the past decade has it been possible to …