We have earlier found that the histamine H3 receptor (H3R) antagonism diminishes
motivational aspects of alcohol reinforcement in mice. Here we studied the role of H3Rs in …

Recent research suggests that histamine H3 receptor (H3R) antagonism may diminish
motivational aspects of alcohol dependence. We studied the role of H3Rs in alcohol-related …

Data from rat models for alcohol preference and histidine decarboxylase knockout (HDC
KO) mice suggest that brain histamine regulates alcohol-related behaviors. Histamine levels …

Background and Purpose Conflicting data have been published on whether histamine is
inhibitory to the rewarding effects of abused drugs. The purpose of this study was to clarify …

Rationale A few recent studies suggest that brain histamine levels and signaling via H 3
receptors play an important role in modulation of alcohol stimulation and reward in rodents …

Rationale Growing evidence supports a role for the central histaminergic system to have a
modulatory influence on drug addiction in general and alcohol-use disorders in particular …

Substance use disorders are a leading cause of morbidity and mortality, and available
pharmacological treatments are of modest efficacy. Histamine is a biogenic amine with four …

The brain histaminergic system is one of the diffuse modulatory neurotransmitter systems
which regulate neuronal activity in many brain areas. Studies on both rats and mice indicate …

The histaminergic system is thought to regulate brain reward, but the exact mechanisms are
poorly understood. This study aims to reveal the pathophysiological differences in the brain …

Histamine H3 receptor (H3R) antagonists are currently being investigated for the possible
therapeutic use in various cognitive deficits such as those in schizophrenia, attention deficit …