Novel gold-platinum nanoparticles serve as broad-spectrum antioxidants for attenuating ischemia reperfusion injury of the kidney

S Feng, Y Qu, B Chu, X Chen, Z Yang, P Li, P Wang… - Kidney International, 2022 - Elsevier
Kidney ischemia reperfusion injury (IRI) is a common and inevitable pathological condition
in routine urological practices, especially during transplantation. Severe kidney IRI may …

Ultrasmall platinum nanozymes as broad-spectrum antioxidants for theranostic application in acute kidney injury

DY Zhang, H Liu, MR Younis, S Lei, C Yang… - Chemical Engineering …, 2021 - Elsevier
Acute kidney injury (AKI) is a common kidney disease with high mortality rate, while
surprisingly, the supportive treatment and renal replacement are the only available clinical …

[HTML][HTML] Clinically translatable gold nanozymes with broad spectrum antioxidant and anti-inflammatory activity for alleviating acute kidney injury

DY Zhang, T Tu, MR Younis, KS Zhu, H Liu, S Lei… - Theranostics, 2021 - ncbi.nlm.nih.gov
Rationale: Acute kidney injury (AKI) is associated with aberrant generation of oxidative
species and inflammation, leading to high mortality of in-hospitalized patients. Although N …

Kidney‐Targeted Nanoparticles Loaded with the Natural Antioxidant Rosmarinic Acid for Acute Kidney Injury Treatment

J Li, Q Duan, X Wei, J Wu, Q Yang - Small, 2022 - Wiley Online Library
Acute kidney injury (AKI) is a common clinical disease with high morbidity and mortality, and
with a lack of effective drugs for treatment. Oxidative stress is very important in the …

Multi-enzyme mimetic ultrasmall iridium nanozymes as reactive oxygen/nitrogen species scavengers for acute kidney injury management

DY Zhang, MR Younis, H Liu, S Lei, Y Wan, J Qu, J Lin… - Biomaterials, 2021 - Elsevier
Acute kidney injury (AKI) is a kind of kidney disease with a high mortality rate, and is
predominantly associated with abundant endogenous reactive oxygen/nitrogen species …

Effects of antioxidant combinations on the renal toxicity induced rats by gold nanoparticles

GM Alshammari, MS Al-Ayed, MA Abdelhalim… - Molecules, 2023 - mdpi.com
This study investigated some possible mechanisms underlying the nephrotoxic effect of gold
nanoparticles (AuNPs) in rats and compared the protective effects of selected known …

An Ultrasmall RuO2 Nanozyme Exhibiting Multienzyme-like Activity for the Prevention of Acute Kidney Injury

Z Liu, L Xie, K Qiu, X Liao, TW Rees… - … applied materials & …, 2020 - ACS Publications
Oxidative stress induced by reactive oxygen species (ROS) is one of the major pathological
mechanisms of acute kidney injury (AKI). Inorganic nanomaterial-mediated antioxidant …

Gold nanoparticles induce oxidative stress and apoptosis in human kidney cells

M Enea, E Pereira, M Peixoto de Almeida, AM Araújo… - Nanomaterials, 2020 - mdpi.com
Gold nanoparticles (AuNPs) are highly attractive for biomedical applications. Therefore,
several in vitro and in vivo studies have addressed their safety evaluation. Nevertheless …

Ceria nanoparticles prophylactic used for renal ischemia-reperfusion injury treatment by attenuating oxidative stress and inflammatory response

L Zhou, S Tang, F Li, Y Wu, S Li, L Cui, J Luo, L Yang… - Biomaterials, 2022 - Elsevier
Renal ischemia-reperfusion (IR) injury (RIRI) is the leading cause of acute kidney injury
(AKI), a common disease with high morbidity and mortality. However, due to the lack of …

Antioxidant nanozymes in kidney injury: mechanism and application

J Wu, H Shang, A Zhang, Y He, Y Tong, Q Huang, X Liu… - Nanoscale, 2023 - pubs.rsc.org
Excessive production of reactive oxygen species (ROS) in the kidney is involved in the
pathogenesis of kidney diseases, such as acute kidney injury (AKI) and diabetic kidney …