Background Administration of general anesthetics to patients with chronic hypertension
often causes hemodynamic instability that has been attributed in part to a poorly understood …

Background The purpose of this study was to compare the effects of isoflurane on
membrane and intracellular mechanisms that regulate vascular smooth muscle (VSM) …

Introduction This study was designed to compare the inhibitory effect of inhaled volatile
anesthetic agents on in situ sympathetic neural versus nonneural regulation of vascular …

Isoflurane is a potent systemic vasodilator. Because isoflurane vasodilation is clinically
significant, we sought to explore whether decreases in systemic vascular resistance caused …

Background A primary source of calcium (Ca2+) necessary for excitation contraction in
vascular smooth muscle (VSM) is influx via voltage-dependent Ca2+ channels. Thus, force …

The vascular response to anesthetics is altered in hypertensive patients since the functional
and structural integrities of vascular smooth muscle and endothelium are deranged. The …

Background It is believed that isoflurane decreases blood pressure predominantly by
decreasing systemic vascular resistance with modest myocardial depression. Nevertheless …

We measured the effects of inhaled isoflurane on hypoxemia-induced changes in the
diameter of small mesenteric (capacitance-regulating) veins, sympathetic efferent neural …

Sevoflurane causes a decrease in mean arterial pressure (MAP). We have studied in
anaesthetized rabbits its interactive effects on MAP, the autonomic nervous system and …

Background. Sevoflurane reduces blood pressure, the regulation of which requires an intact
sympathetic neurotransmission. This study was designed to evaluate the effect of …