Aortic valve regurgitation (AR) can result in heart failure from chronic overloading of the left
ventricle (LV). Little is known of the role of estrogens in the LV responses to this condition …

Methods: AR was created in adult Wistar rats (females (control or OVX) and males). Animals
were followed for 26 weeks and compared to sham-operated groups. Heart function was …

The aim of the study was to characterize if the development of cardiac hypertrophy (CH)
caused by severe left ventricle (LV) volume overload (VO) from chronic aortic valve …

Obesity and menopause lead to cardiovascular diseases. Calorie restriction (CR) can
modulate estrogen deficiency and obesity-related cardiovascular diseases. The protective …

To elucidate the molecular mechanism underlying estrogen-mediated cardioprotection in left
ventricular (LV) hypertrophy and remodeling, we analyzed myocardial hypertrophy as well …

Background Aortic valve regurgitation (AR) results in left ventricle (LV) volume overload (VO)
leading to its dilation and hypertrophy (H). We study a rat model of severe AR induced by …

We have previously demonstrated the cardioprotective effects of ovarian hormones against
adverse ventricular remodeling imposed by chronic volume overload. Here, we assess the …

Aortic valve regurgitation (AR) imposes a volume overload (VO) to the left ventricle (LV).
Male rats with a pathological heart overload usually progress more quickly towards heart …

Aims Oestrogen receptor alpha (ERα) and beta (ERβ) are involved in the regulation of
pathological myocardial hypertrophy (MH). We hypothesize that both ER are also involved in …

The aim of this study was to investigate the effects of 17β-estradiol (E2), the selective ERα
agonist 16α-LE2, and the selective estrogen receptor modulator (SERM) raloxifene on …