Nirmatrelvir and risk of hospital admission or death in adults with covid-19: emulation of a randomized target trial using electronic health records

Y Xie, B Bowe, Z Al-Aly - bmj, 2023 - bmj.com
Objective To estimate the effectiveness of nirmatrelvir, compared with no treatment, in
reducing admission to hospital or death at 30 days in people infected with the SARS-CoV-2 …

Non-randomized evaluation of hospitalization after a prescription for nirmatrelvir/ritonavir versus molnupiravir in high-risk COVID-19 outpatients

K Cowman, A Miller, Y Guo, MH Chang… - Journal of …, 2023 - academic.oup.com
Objectives To assess and compare subsequent hospital admissions within 30 days for
patients after receiving a prescription for either oral nirmatrelvir/ritonavir or oral molnupiravir …

Comparison of effectiveness and safety of nirmatrelvir/ritonavir versus sotrovimab for COVID-19: a systematic review and meta-analysis

B Amani, B Amani - Expert Review of Anti-infective Therapy, 2024 - Taylor & Francis
Background This study aims to compare the effectiveness and safety of nirmatrelvir/ritonavir
(Paxlovid) and sotrovimab for coronavirus disease 2019 (COVID-19). Methods A search was …

Prevalence of contraindications to nirmatrelvir-ritonavir among hospitalized patients with COVID-19 at risk for progression to severe disease

N Hoertel, DR Boulware, M Sánchez-Rico… - JAMA Network …, 2022 - jamanetwork.com
The availability of outpatient treatment options for COVID-19, such as nirmatrelvir-ritonavir,
remdesivir, molnupiravir, and monoclonal antibodies, raises hopes for reducing COVID-19 …

[HTML][HTML] Antiviral drug treatment for nonsevere COVID-19: a systematic review and network meta-analysis

T Pitre, R Van Alstine, G Chick, G Leung, D Mikhail… - Cmaj, 2022 - Can Med Assoc
Background: Randomized trial evidence suggests that some antiviral drugs are effective in
patients with COVID-19. However, the comparative effectiveness of antiviral drugs in …

Efficacy and safety of nirmatrelvir/ritonavir (Paxlovid) for COVID‐19: a rapid review and meta‐analysis

B Amani, B Amani - Journal of Medical Virology, 2023 - Wiley Online Library
This study aimed to examine the efficacy and safety of nirmatrelvir/ritonavir (Paxlovid) for
coronavirus disease 2019 (COVID‐19). PubMed, Cochrane Library, Web of Science …

Nirmatrelvir/ritonavir for the treatment of immunocompromised adult patients with early‐stage symptomatic COVID‐19: A real‐life experience

JM Caso, M Fernández‐Ruiz… - Journal of Medical …, 2023 - Wiley Online Library
Regardless of vaccination status, progression to severe coronavirus disease 2019 (COVID‐
19) is still a relevant cause of morbidity among immunocompromised patients. Despite the …

Identifying Veterans Who Benefit From Nirmatrelvir-Ritonavir: A Target Trial Emulation

L Yan, D Bui, Y Li, N Rajeevan… - Clinical Infectious …, 2024 - academic.oup.com
Background Nirmatrelvir-ritonavir is recommended for persons at risk for severe coronavirus
disease 2019 (COVID-19) but remains underutilized. Information on which eligible groups …

Effectiveness of Nirmatrelvir–Ritonavir Against the Development of Post–COVID-19 Conditions Among US Veterans: A Target Trial Emulation

GN Ioannou, K Berry, N Rajeevan, Y Li… - Annals of internal …, 2023 - acpjournals.org
Background: COVID-19 has been linked to the development of many post–COVID-19
conditions (PCCs) after acute infection. Limited information is available on the effectiveness …

Oral Molnupiravir and Nirmatrelvir/Ritonavir for the Treatment of COVID-19: A Literature Review with a Focus on Real-World Evidence

I Karniadakis, N Mazonakis, C Tsioutis… - Infectious Disease …, 2023 - mdpi.com
Vaccines remain the cornerstone of medical prevention and are highly effective in reducing
the risk of severe disease and death due to coronavirus disease 2019 (COVID-19). In the …