Aims Acetaminophen (APAP) overdose leads to severe hepatotoxicity. Isoquercitrin
exhibited potential hepatoprotective effect in our previous study. The present investigation …

Oxidative stress has been highlighted as therapeutic targets for acetaminophen (APAP)-
induced hepatotoxicity. Isoorientin (Iso), a well-known flavonoid-like compound, has been …

Acetaminophen (APAP) overdose may lead to the formation of oxidative stress, hepatocyte
apoptosis and necrosis, and, eventually result in acute liver failure. Escin, a major extracted …

Acetaminophen (APAP) overdose causes acute liver injury and leads to fatal liver damage.
However, the therapies are quite limited. Shikonin is a natural product with antioxidant and …

Simple Summary Acetaminophen overdose causes acute liver injury by excessive oxidative
stress. The present study examines the mechanisms underlying the protective effect of …

Acetaminophen (APAP) overdose is the main cause of acute liver failure. Apigenin (API) is a
natural dietary flavonol with high antioxidant capacity. Herein, we investigated protection by …

Acetaminophen (APAP) overdose leads to liver injury. NLRP3 inflammasome is a key player
in APAP‐induced inflammation. Also, apoptosis and liver regeneration play an important …

Corilagin is a major active polyphenolic tannins extracted from Phyllanthus urinaria, an
important herb used in traditional medicine. Previous reports demonstrated that corilagin …

Acetaminophen (APAP)-induced acute liver injury (ALI) is the principal cause of acute liver
failure (ALF) in some countries including the United States and with few available …

Hepatotoxicity induced by acetaminophen (APAP)‐overdose is a major concern in clinical
practice. In the present work, the detoxifying effect of irbesartan (Irb) on the APAP‐induced …