Acetaminophen (APAP) overdose-induced hepatotoxicity is the most common cause of drug-
induced liver injury worldwide, which is significantly linked to oxidative stress and sterile …

Acetaminophen (APAP) overdose accounts for the majority of acute liver failure cases, and
oxidative stress plays a key role in its toxic effects. Esculentoside A (EsA) has anti-oxidant …

Aim In this study, we aimed to examine the efficacy of thymoquinone (TQ) treatment in
acetaminophen-induced liver toxicity in rats. Methods Forty Wistar Albino rats were used for …

Acetaminophen-induced liver injury represents the most frequent cause of drug-induced
liver failure in the world. Portulaca oleracea L., a widely distributed weed, has been used as …

The present study was carried out to investigate whether taurine plays any beneficial role in
acetaminophen (APAP)-induced acute hepatotoxicity. APAP exposure increased the plasma …

Abstract Aims: Acetaminophen (APAP)-induced liver injury is mainly due to the excessive
formation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) through the …

Oxidative stress, as an important pathogenic factor, plays a critical role in acetaminophen
(APAP) overdose-induced acute liver failure (ALF). Thus, an antioxidative strategy may be a …

Acetaminophen (APAP) overdose is the leading cause of acute liver failure (ALF) in the
Western world, with limited treatment opportunities. 3, 5, 7, 4′-Tetrahydroxyflavanone …

Acetaminophen (APAP)-induced acute hepatotoxicity is the leading cause of drug-induced
acute liver failure. The aim of this study was to evaluate the effects of 4-hydroxy-2, 2, 6, 6 …

The hepatotoxicity induced by APAP is caused by the excessive production of N-acetyl-para-
benzoquinone imine (NAPQI), which, when reacting with hepatic proteins proved to cause …