Human papillomavirus (HPV) E2 proteins regulate viral replication by binding to sites in the
upstream regulatory region (URR) and by complex formation with the E1 origin recognition …

Viral proteins E1 and E2 are essential for transient human papillomavirus (HPV) DNA
replication. E1 is a multifunctional protein which can bind DNA and complex with E2, has …

The activation of transcription and of DNA replication are, in some cases, mediated by the
same proteins. A prime example is the E2 protein of human papillomaviruses (HPVs), which …

The papillomavirus E2 protein is required for viral transcriptional regulation and replication.
The E2 protein has a modular structure with two highly conserved domains, a sequence …

The human papillomavirus type 18 E1 and E2 proteins are both required for the initiation of
viral DNA replication. Whereas E2 is the major viral transcription regulator, E1 is the …

Replication of papillomaviruses requires an origin of replication and two virus-encoded
proteins, E1 and E2. Using a transient replication assay for human papillomavirus type 18 …

The papillomavirus E1 and E2 proteins form heteromeric complexes and individually bind
specific sequences within the viral origin of replication. The mechanism by which these …

Replication of human papillomavirus type 11 (HPV-11) DNA requires the full-length viral E1
and E2 proteins (C.-M. Chiang, M. Ustav, A. Stenlund, TF Ho, TR Broker, and LT Chow, Proc …

The most highly expressed protein in the productive life cycle of human papillomaviruses
(HPVs) is E1∧ E4, but its function is not well understood. To investigate the role of E1∧ E4 …

The papillomavirus E1 and E2 proteins are both necessary and sufficient in vivo for efficient
origin-dependent viral DNA replication. The ability of E1 and E2 to complex with each other …