Spatially resolved human kidney multi-omics single cell atlas highlights the key role of the fibrotic microenvironment in kidney disease progression
Kidneys possess one of the most intricate three-dimensional cellular structures in the body,
yet the spatial and molecular principles of kidney health and disease remain inadequately …
yet the spatial and molecular principles of kidney health and disease remain inadequately …
Single-cell multi-omic and spatial profiling of human kidneys implicates the fibrotic microenvironment in kidney disease progression
Kidneys are intricate three-dimensional structures in the body, yet the spatial and molecular
principles of kidney health and disease remain inadequately understood. We generated …
principles of kidney health and disease remain inadequately understood. We generated …
Spatially resolved transcriptomes of mammalian kidneys illustrate the molecular complexity and interactions of functional nephron segments
Available transcriptomes of the mammalian kidney provide limited information on the spatial
interplay between different functional nephron structures due to the required dissociation of …
interplay between different functional nephron structures due to the required dissociation of …
Comprehensive cell type specific transcriptomics of the human kidney
The human kidney is a complex organ composed of specialized cell types. To better define
this cellular complexity, we profiled the individual transcriptomes of 22,469 normal human …
this cellular complexity, we profiled the individual transcriptomes of 22,469 normal human …
A reference tissue atlas for the human kidney
Kidney Precision Medicine Project (KPMP) is building a spatially specified human kidney
tissue atlas in health and disease with single-cell resolution. Here, we describe the …
tissue atlas in health and disease with single-cell resolution. Here, we describe the …
Single‐cell RNA‐seq with spatial transcriptomics to create an atlas of human diabetic kidney disease
D Chen, M Shao, Y Song, G Ren, F Guo… - The FASEB …, 2023 - Wiley Online Library
Diabetic kidney disease (DKD) develops in~ 40% of patients with diabetes and is the
leading cause of chronic kidney disease worldwide. We used single‐cell RNA‐sequencing …
leading cause of chronic kidney disease worldwide. We used single‐cell RNA‐sequencing …
A comprehensive mouse kidney atlas enables rare cell population characterization and robust marker discovery
C Novella-Rausell, M Grudniewska, DJM Peters… - Iscience, 2023 - cell.com
The kidney's cellular diversity is on par with its physiological intricacy; yet identifying cell
populations and their markers remains challenging. Here, we created a comprehensive …
populations and their markers remains challenging. Here, we created a comprehensive …
Single-cell transcriptomic profiles in the pathophysiology within the microenvironment of early diabetic kidney disease
YC Tsai, MC Kuo, JC Huang, WA Chang, LY Wu… - Cell Death & …, 2023 - nature.com
Diabetic kidney disease (DKD) is the leading cause of end-stage kidney disease, resulting
in a huge socio-economic impact. Kidney is a highly complex organ and the pathogenesis …
in a huge socio-economic impact. Kidney is a highly complex organ and the pathogenesis …
Spatially resolved transcriptomics and the kidney: many opportunities
EE Dixon, H Wu, E Sulvarán-Guel, J Guo… - Kidney International, 2022 - Elsevier
Defining changes in gene expression during health and disease is critical for the
understanding of human physiology. In recent years, single-cell/nuclei RNA sequencing …
understanding of human physiology. In recent years, single-cell/nuclei RNA sequencing …
An atlas of healthy and injured cell states and niches in the human kidney
Understanding kidney disease relies on defining the complexity of cell types and states, their
associated molecular profiles and interactions within tissue neighbourhoods. Here we …
associated molecular profiles and interactions within tissue neighbourhoods. Here we …