Thymoquinone loaded solid lipid nanoparticles demonstrated antidepressant-like activity in rats via indoleamine 2, 3-dioxygenase pathway
The World Health Organization (WHO) has ranked depression the 4 th leading cause of
disability worldwide. Thymoquinone (TQ), is an active constituent of Nigella sativa having …
disability worldwide. Thymoquinone (TQ), is an active constituent of Nigella sativa having …
Formulation and evaluation of nano lipid formulation containing CNS acting drug: molecular docking, in-vitro assessment and bioactivity detail in rats
The study performed molecular docking, formulated, characterized thymoquinone (TQ)
loaded solid lipid nano particles (TQSLN) and exhibited comparative antidepressant activity …
loaded solid lipid nano particles (TQSLN) and exhibited comparative antidepressant activity …
Thymoquinone lipid nanoparticles cut the Gordian knots of depression via neuroprotective BDNF and downregulation of neuro-inflammatory NF-κB, IL-6, and TNF-α in …
Background: In over 300 million clinical cases, antidepressant drugs seem to provide only
symptomatic relief and limited protection in life-threatening depressive events. Objectives …
symptomatic relief and limited protection in life-threatening depressive events. Objectives …
A novel therapeutic application of solid lipid nanoparticles encapsulated thymoquinone (TQ-SLNs) on 3-nitroproponic acid induced Huntington's disease-like …
S Ramachandran, S Thangarajan - Chemico-Biological Interactions, 2016 - Elsevier
Abstract Huntington's disease (HD), a devastating neurodegenerative disease causing a
remarkable pathogenesis involves mitochondrial dysfunction and bioenergetics failure. 3 …
remarkable pathogenesis involves mitochondrial dysfunction and bioenergetics failure. 3 …
Thymoquinone loaded solid lipid nanoparticles counteracts 3-Nitropropionic acid induced motor impairments and neuroinflammation in rat model of Huntington's …
S Ramachandran, S Thangarajan - Metabolic Brain Disease, 2018 - Springer
Defect in gene transcription, excitotoxicity, neuroinflammation and oxidative stress are the
dominant disease process that causes striatal cell loss with motor abnormalities in …
dominant disease process that causes striatal cell loss with motor abnormalities in …
Protective roles of thymoquinone nanoformulations: potential nanonutraceuticals in human diseases
The focus on nanotechnology for improved bioavailability and drug delivery is of increasing
importance for control of different human diseases. Therefore, numerous nanoformulations …
importance for control of different human diseases. Therefore, numerous nanoformulations …
Neuroprotective effects of niosomes loaded with thymoquinone in the cerebral ischemia model of male Wistar rats
SH Nemati, MR Bigdeli, FM Moghadam… - … , Biology and Medicine, 2023 - Elsevier
The complex stroke pathophysiology, like oxidative stress and inflammatory reactions,
causes substantially challenged in stroke treatment. Thymoquinone (TQ) is attributed to …
causes substantially challenged in stroke treatment. Thymoquinone (TQ) is attributed to …
The role of thymoquinone in inflammatory response in chronic diseases
Y Liu, L Huang, MY Kim, JY Cho - International Journal of Molecular …, 2022 - mdpi.com
Anti-inflammatory therapies have been shown to be effective in the prevention of various
cardiovascular diseases, tumors, and cancer complications. Thymoquinone (TQ), the main …
cardiovascular diseases, tumors, and cancer complications. Thymoquinone (TQ), the main …
Thymoquinone protects neurons in the cerebellum of rats through mitigating oxidative stress and inflammation following high-fat diet supplementation
A Alrafiah - Biomolecules, 2021 - mdpi.com
High-fat diet (HFD) is a major problem causing neuronal damage. Thymoquinone (TQ) could
regulate oxidative stress and the inflammatory process. Hence, the present study elucidated …
regulate oxidative stress and the inflammatory process. Hence, the present study elucidated …
Therapeutic potential of thymoquinone and its nanoformulations in pulmonary injury: a comprehensive review
NA Al-Gabri, SAM Saghir, SA Al-Hashedi… - International journal …, 2021 - Taylor & Francis
As a crucial organ, the lung is exposed to various harmful agents that may induce
inflammation and oxidative stress, which may cause chronic or acute lung injury. Nigella …
inflammation and oxidative stress, which may cause chronic or acute lung injury. Nigella …