The cardiac renin–angiotensin–aldosterone system (RAAS) is an endocrine cascade, which
results in the conversion of the inactive pro-hormone angiotensin I (Ang I) to the active …

For decades, the literature has been inundated with evi-dence of the important role of the
renin–angiotensin system (RAS) in cardiac remodeling and function with most in the field …

Abstract Angiotensin II (Ang II), a bioactive peptide of the renin–angiotensin system (RAAS),
plays an important role in the development of cardiovascular diseases (CVD) …

Background ACE2 is a novel homologue of angiotensin converting enzyme (ACE). ACE2 is
highly expressed in human heart and animal data suggest that ACE2 is an essential …

ACE2 is confined to the endothelium, 10 but further studies showed ACE2 expression in
cardiomyocytes, 17 in the kidney on the luminal surface of tubular epithelial cells, 10, 18 and …

Abstract Angiotensin-converting enzyme 2 (ACE2) metabolizes Ang II into Ang 1–7 thereby
negatively regulating the renin-angiotensin system. However, heart disease in humans and …

Aims Angiotensin converting enzyme (ACE) 2 catalyses the cleavage of angiotensin (Ang) I
to Ang 1‐9 and of Ang II to Ang 1‐7. ACE2 deficiency impairs cardiac contractility and …

Cardiovascular disease is the greatest health care burden and one of the most common
causes of death worldwide. Less is known about the genetic factors that are responsible for …

Angiotensin-converting enzyme 2 (ACE2) preferentially forms angiotensin-(1-7)[ANG-(1-7)]
from ANG II. We showed that cardiac ACE2 is elevated following treatment of coronary artery …

A novel angiotensin-converting enzyme (ACE) homolog, named ACE2, is a
monocarboxypeptidase which metabolizes several peptides. ACE2 degrades Angiotensin …