Development of the human placenta takes place in contrasting oxygen concentrations at
different stages of gestation, from~ 20 mmHg during the first trimester rising to~ 60 mmHg at …

BACKGROUND The placenta is the functional interface between the mother and the fetus
during pregnancy, and a critical determinant of fetal growth and life-long health. In the first …

Towards the end of the first trimester, blood flow and oxygenation rise within the placenta,
supporting an increased capacity for mitochondrial oxidative metabolism in both the …

Oxygen is necessary for life yet too much or too little oxygen is toxic to cells. The oxygen
tension in the maternal plasma bathing placental villi is< 20mmHg until 10–12 weeks' …

Compared to other mammals, implantation in the human establishes a precocious and
intimate apposition between the maternal and fetal tissues. In the past it has been assumed …

Hemochorial placentation is orchestrated through highly regulated temporal and spatial
decisions governing the fate of trophoblast stem/progenitor cells. Trophoblast cell …

Development of the human placenta is modulated heavily by the intrauterine environment.
During the first trimester, development takes place in a low oxygen environment supported …

Oxygen levels in the placental microenvironment throughout gestation are not constant, with
severe hypoxic conditions present during the first trimester. This hypoxic phase overlaps …

3. Rodesch, F., Simon, P., Donner, C., and Jauniaux, E. 1992. Oxygen measurements in
endometrial and trophoblastic tissues during early pregnancy. Obstet. Gynecol. 80: 283 …

At term of pregnancy, oxygen consumption by the human or ovine placenta accounts for 40
per cent of total oxygen uptake by the gravid uterus. In the sheep, most oxygen is used for …