Aims/hypothesis The initial avascular period following islet transplantation seriously
compromises graft function and survival. Enhancing graft revascularisation to improve …

Aims/hypothesis Delivery of the gene for human vascular endothelial growth factor (VEGF,
also known as VEGFA) to both the transplanted islets and the surrounding tissue may …

Successful islet transplantation depends on the infusion of sufficiently large quantities of
islets, of which only∼ 30% become stably engrafted. Rapid and adequate revascularization …

Early revascularization of pancreatic islet cells after transplantation is crucial for engraftment,
and it has been suggested that vascular endothelial growth factor-A (VEGF-A) plays a …

Background. Delayed angiogenesis remains a significant challenge to the survival of
transplanted islets. In this study, using a murine model of subcutaneous islet transplantation …

PURPOSE: Transplantation of pancreas islet has been worldwidely studied as a one of
therapeutic modalities to achieve the insulin independence. We studied whether the …

For gene transfer strategies to improve islet engraftment, vascular endothelial growth factor
(VEGF) expression should be regulated in a way that matches the transient nature of …

AIM: To determine whether the elevated vascular endothelial growth factor (VEGF)
expression produced by the transfected vascular endothelial cells (VECs) could stimulate …

Islet transplantation has been hampered by loss of function due to poor revascularization.
We hypothesize that co-transplantation of islets with human embryonic stem cell-derived …

Background. Insufficient revascularization of transplanted islets may result in chronic
hypoxia and loss of islet function. This study investigated whether simple culture of islets …