Purpose Ex vivo gene therapy approaches can improve the outcome of islet transplantation
for treating type I diabetes. We have previously shown the improvement in islet function and …

Background. Blood flow is impaired in islet transplants, but there is conflicting evidence on
improving the outcome by promoting vascularization. We previously reported that islet …

Ex vivo gene therapy approaches can improve the outcome of islet transplantation for
treating type I diabetes. We have recently shown improvement in islet survival and function …

Islet transplantation is limited by islet graft failure due to poor revascularization, host immune
rejection and nonspecific inflammatory response. Delivery of human vascular endothelial …

Purpose. Islet transplantation is limited by islet graft failure because of poor
revascularization, host immune rejection, and nonspecific inflammatory response. Human …

Lack of rapid revascularization and inflammatory attacks at the site of transplantation
contribute to impaired islet engraftment and suboptimal metabolic control after clinical islet …

Aims/hypothesis Vascular endothelial growth factor (VEGF) is essential for proper pancreatic
development, islet vascularisation and insulin secretion. In the adult pancreas, VEGF is …

Transplantation of pancreatic islets is proposed as a treatment for type 1 diabetes, but
insufficient blood supply can cause the loss of viable grafted islets. In the present study, we …

Although pancreatic islets comprise only 1–2% of pancreatic mass, they receive 5–10% of
pancreatic blood flow. Blood vessels within pancreatic islets are of a greater density than …

Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen with potent
angiogenic and vascular permeability-inducing properties, both of which may be important …