Obesity is strongly associated with ill health, primarily caused by consumption of excessive
calories, and promoted (inter alia) by gamma-amino-butyric-acid (GABA) stimulating food …

Objective Large weight gain during pregnancy is a risk factor for complications for mother
and fetus. Hunger and satiety are regulated in the hypothalamus, where the gamma-amino …

Allopregnanolone is a neuroactive metabolite of progesterone. Allopregnanolone is
synthesized from progesterone by the sequential actions of two enzymes, 5α-reductase type …

Ingestion of energy rich high fat diets is one of the determining factors associated with the
obesity epidemic. Therefore, much can be learned from studies of obesity-related …

GABA is the main inhibitory neurotransmitter in the brain and GABAergic transmission has
been shown to be of importance for regulation of mood, memory and food intake. The …

Abstract 3α-5α-Tetrahydroprogesterone, a progesterone metabolite also known as
allopregnanolone, and 5α-androstane-3α, 17β-diol, a testosterone metabolite also known as …

Allopregnanolone is an endogenous neurosteroid that acts in a rapid non-genomic manner
to enhance the function of the GABA A receptor (GABA AR), the major inhibitory receptor in …

Abstract Allopregnanolone (3α-hydroxy-5α-pregnan-20-one) is a major cholesterol-derived
neurosteroid in the central nervous system and is synthesized from progesterone by …

Objective: Several studies demonstrated that obese subjects have a hyperactive
hypothalamic-pituitary-adrenal axis and that sex steroid hormones have been closely …

The hypothalamic release of glutamate and GABA regulates neurosecretory functions that
may control the onset of puberty. This release may be influenced by neurosteroids such as …