ABSTRACT Phospholipase C (PLC) of Cryptococcus neoformans (Cn Plc1) is crucial for
virulence of this fungal pathogen. To investigate the mechanism of CnPlc1-mediated …

Cryptococcus neoformans causes deadly mycosis in immunocompromised individuals.
Macrophages are key cells fighting against microbes. Extracellular vesicles (EVs) are cell-to …

A defect in the PKA1 gene encoding the catalytic subunit of cyclic adenosine 5′-
monophosphate (cAMP)–dependent protein kinase A (PKA) is known to reduce capsule size …

Cryptococcus neoformans is an opportunistic fungus that can cause lethal brain infections in
immunosuppressed individuals. Infection usually occurs via the inhalation of a spore or …

Cryptococcosis is a systemic fungal infection caused by Cryptococcus neoformans. In
immunocompetent patients, cryptococcal infection is often confined to the lungs. In …

Invasive fungal infections, including cryptococcosis, are a growing threat to
immunocompromised patients. Although Cryptococcus neoformans and Cryptococcus gattii …

Cryptococcus neoformans is a human-pathogenic fungal pathogen that causes life-
threatening meningoencephalitis in immunocompromised individuals. To investigate the …

The cell walls of fungi are critical for cellular structure and rigidity but also serve as a major
communicator to alert the cell to the changing environment. In response to stresses …

Cryptococcus neoformans is an important human fungal pathogen for which the external
environment is its primary niche. Previous work has shown that two nonessential acetyl-CoA …

Whereas extracellular vesicle (EV) research has become commonplace in different
biomedical fields, this field of research is still in its infancy in mycology. Here we provide a …