Abstract Polo-like kinase 4 (PLK4) belongs to the family of polo-like kinases (PLK1-5), an
evolutionarily conserved family of serine/threonine kinases containing a characteristic polo …

The human Polo-like kinase 1 (PLK1) and its functional homologues that are present in
other eukaryotes have multiple, crucial roles in meiotic and mitotic cell division,. By contrast …

Mammalian spermatogenesis is comprised of two consecutive meiotic divisions, producing
four haploid spermatids. The precision and accuracy of such a process are dependent on …

The four mammalian Polo like kinases (Plks), Plk1, Plk2, Plk3, and Plk4, are regulators of
cell cycle progression. Plks are distinguished by the presence of an N-terminal Ser/Thr …

ABSTRACT Polo-like kinase 1 (PLK1) plays a fundamental role in the spatiotemporal control
of mitosis. Cells lacking PLK1 activity exhibit characteristic chromosome misalignment due …

Abstract Polo-like kinase (PLK) 4 is a unique member of the PLK family that plays vital roles
in centriole biogenesis during mitosis. The localization of PLK4 on centrioles must be …

Meiosis is the process in which one diploid cell is divided into four haploid gametes. This
process must be tightly regulated, as errors can result in infertility, genetic mutation, or …

During cell division, duplicated genetic material is separated into two distinct daughter cells.
This process is essential for initial tissue formation during development and to maintain …

Mitosis is coordinated by carefully controlled phosphorylation and ubiquitin-mediated
proteolysis. Polo-like kinase 1 (Plk1) plays a central role in regulating mitosis and …

Homologous recombination (HR) is an essential meiotic process that contributes to the
genetic variation of offspring and ensures accurate chromosome segregation …