Therapeutic targeting of Toll-like receptors for infectious and inflammatory diseases and cancer
Since first being described in the fruit fly Drosophila melanogaster, Toll-like receptors (TLRs)
have proven to be of great interest to immunologists and investigators interested in the …
have proven to be of great interest to immunologists and investigators interested in the …
Potential therapeutic targets for inflammation in toll-like receptor 4 (TLR4)-mediated signaling pathways
Inflammation is set off when innate immune cells detect infection or tissue injury. Tight
control of the severity, duration, and location of inflammation is an absolute requirement for …
control of the severity, duration, and location of inflammation is an absolute requirement for …
Trial watch: TLR3 agonists in cancer therapy
ABSTRACT Toll-like receptor 3 (TLR3) is a pattern recognition receptor that senses
exogenous (viral) as well as endogenous (mammalian) double-stranded RNA in …
exogenous (viral) as well as endogenous (mammalian) double-stranded RNA in …
[HTML][HTML] Toll-like receptors as a therapeutic target in the era of immunotherapies
Toll-like receptors (TLRs) are the pattern recognition receptors, which are activated by
foreign and host molecules in order to initiate the immune response. They play a crucial role …
foreign and host molecules in order to initiate the immune response. They play a crucial role …
Toll‐like receptors: the swiss army knife of immunity and vaccine development
JK Dowling, A Mansell - Clinical & translational immunology, 2016 - Wiley Online Library
Innate immune cells have a critical role in defense against infection and disease. Central to
this is the broad specificity with which they can detect pathogen‐associated patterns and …
this is the broad specificity with which they can detect pathogen‐associated patterns and …
Toll-like receptors in immunity and inflammatory diseases: Past, present, and future
K Vijay - International immunopharmacology, 2018 - Elsevier
The immune system is a very diverse system of the host that evolved during evolution to
cope with various pathogens present in the vicinity of environmental surroundings inhabited …
cope with various pathogens present in the vicinity of environmental surroundings inhabited …
Therapeutic targeting of Toll-like receptors for inflammatory and infectious diseases
LAJ O'Neill - Current opinion in pharmacology, 2003 - Elsevier
Roles for Toll-like receptors (TLRs) are emerging in conditions such as sepsis syndrome,
systemic lupus erythromatosis, rheumatoid arthritis and asthma, suggesting that the …
systemic lupus erythromatosis, rheumatoid arthritis and asthma, suggesting that the …
Trial Watch: Experimental Toll-like receptor agonists for cancer therapy
L Galluzzi, E Vacchelli, A Eggermont… - …, 2012 - Taylor & Francis
Toll-like receptors (TLRs) are prototypic pattern recognition receptors (PRRs) best known for
their ability to activate the innate immune system in response to conserved microbial …
their ability to activate the innate immune system in response to conserved microbial …
Toll-like receptors: promising therapeutic targets for inflammatory diseases
The health of living organisms is constantly challenged by bacterial and viral threats. The
recognition of pathogenic microorganisms by diverse receptors triggers a variety of host …
recognition of pathogenic microorganisms by diverse receptors triggers a variety of host …
New developments in Toll-like receptor targeted therapeutics
DJ Connolly, LAJ O'Neill - Current opinion in pharmacology, 2012 - Elsevier
Toll-like receptors (TLRs) play a crucial role in host defence and inflammation. Given that a
significant amount of evidence implicates TLRs in the pathogenesis of immune diseases …
significant amount of evidence implicates TLRs in the pathogenesis of immune diseases …