Nephron formation continues throughout kidney morphogenesis in both mice and humans.
Lineage tracing studies in mice identified a self‐renewing Six2‐expressing nephron …

Development of physiologically relevant cellular models with strong translatability to human
pathophysiology is critical for identification and validation of novel therapeutic targets …

An in vitro model of the human kidney glomerulus—the major site of blood filtration—could
facilitate drug discovery and illuminate kidney-disease mechanisms. Microfluidic organ-on-a …

Recent advances in 3D culture technology allow embryonic and adult mammalian stem cells
to exhibit their remarkable self-organizing properties, and the resulting organoids reflect key …

The shortage of transplantable organs provides an impetus to develop tissue-engineered
alternatives. Producing tissues similar to immature kidneys from simple suspensions of fully …

Diseases affecting the kidney constitute a major health issue worldwide. Their incidence and
poor prognosis affirm the urgent need for the development of new therapeutic strategies …

Human organoids allow the study of proliferation, lineage specification, and 3D tissue
development. Here we present a genome-wide CRISPR screen in induced pluripotent stem …

Polycystic kidney disease (PKD) is a life-threatening disorder, commonly caused by defects
in polycystin-1 (PC1) or polycystin-2 (PC2), in which tubular epithelia form fluid-filled cysts …

Direct reprogramming by forced expression of transcription factors can convert one cell type
into another. Thus, desired cell types can be generated bypassing pluripotency. However …

The use of biomimetic models of the glomerulus has the potential to improve our
understanding of the pathogenesis of kidney diseases and to enable progress in …