Isoorientin attenuates doxorubicin-induced cardiac injury via the activation of MAPK, Akt, and Caspase-dependent signaling pathways
S Li, H Liu, Z Lin, Z Li, Y Chen, B Chen, L Huang, X Lin… - Phytomedicine, 2022 - Elsevier
Background Chemotherapy drugs especially anthracyclines are widely used in the treatment
of hematological malignancies and solid tumors. However, their clinical application is limited …
of hematological malignancies and solid tumors. However, their clinical application is limited …
Isoorientin induces the apoptosis and cell cycle arrest of A549 human lung cancer cells via the ROS‑regulated MAPK, STAT3 and NF‑κB signaling pathways
WT Xu, GN Shen, TZ Li, Y Zhang… - International …, 2020 - spandidos-publications.com
Isoorientin (ISO) is a naturally occurring C‑glycosyl flavone that has various pharmacological
properties, such as anti‑bacterial and anti‑inflammatory effects. However, its underlying …
properties, such as anti‑bacterial and anti‑inflammatory effects. However, its underlying …
Isoorientin induces apoptosis through mitochondrial dysfunction and inhibition of PI3K/Akt signaling pathway in HepG2 cancer cells
Isoorientin (ISO) is a flavonoid compound that can be extracted from several plant species,
such as Phyllostachys pubescens, Patrinia, and Drosophyllum lusitanicum; however, its …
such as Phyllostachys pubescens, Patrinia, and Drosophyllum lusitanicum; however, its …
MAPK signaling pathways regulate mitochondrial-mediated apoptosis induced by isoorientin in human hepatoblastoma cancer cells
L Yuan, J Wang, H Xiao, W Wu, Y Wang… - Food and Chemical …, 2013 - Elsevier
Isoorientin (ISO)(CAS RN: 4261-42-1) is a flavonoid compound that can be extracted from
several plant species, such as Phyllostachys pubescens, Patrinia, and Drosophyllum …
several plant species, such as Phyllostachys pubescens, Patrinia, and Drosophyllum …
Anti-apoptotic effect and the mechanism of orientin on ischaemic/reperfused myocardium
XC Fu, MW Wang, SP Li, HL Wang - Journal of Asian natural …, 2006 - Taylor & Francis
We investigated the anti-apoptotic effect of orientin, from bamboo leaves (Phyllostachys
nigra), on rat heart after treatment with ischemia/reperfusion (I/R), and on rat cardiomyocytes …
nigra), on rat heart after treatment with ischemia/reperfusion (I/R), and on rat cardiomyocytes …
[HTML][HTML] Orientin reduces myocardial infarction size via eNOS/NO signaling and thus mitigates adverse cardiac remodeling
F Li, J Zong, H Zhang, P Zhang, L Xu, K Liang… - Frontiers in …, 2017 - frontiersin.org
Orientin is a flavonoid extracted from Chinese traditional herb, Polygonum orientale L.
Previous study has reported that orientin protected myocardial from ischemia reperfusion …
Previous study has reported that orientin protected myocardial from ischemia reperfusion …
Eupatilin attenuates doxorubicin-induced cardiotoxicity by activating the PI3K-AKT signaling pathway in mice
Y Lu, Q Min, X Zhao, L Li, G Zhao, J Dong - Molecular and Cellular …, 2024 - Springer
Eupatilin is a pharmacologically active flavonoid with a variety of biological activities, such
as anticancer, anti-inflammatory, antioxidant, neuroprotective, anti-allergic and …
as anticancer, anti-inflammatory, antioxidant, neuroprotective, anti-allergic and …
Isodunnianol alleviates doxorubicin-induced myocardial injury by activating protective autophagy
C Chen, L Jiang, M Zhang, X Pan, C Peng, W Huang… - Food & function, 2019 - pubs.rsc.org
Recurrent cardiotoxicity limits the clinical application of doxorubicin (DOX); however the
detailed molecular mechanism of DOX cardiotoxicity remains unclear. In the current study …
detailed molecular mechanism of DOX cardiotoxicity remains unclear. In the current study …
Isoorientin protects BRL-3A rat liver cell against hydrogen peroxide-induced apoptosis by inhibiting mitochondrial dysfunction, inactivating MAPKs, activating Akt and …
L Yuan, X Ren, Y Wu, J Wang, H Xiao, X Liu - Biomedicine & Aging …, 2013 - Elsevier
Isoorientin (ISO) is a flavonoid compound, and possesses a significant antioxidant potential.
However, the effects of ISO on the oxidative damage in normal hepatocytes remain …
However, the effects of ISO on the oxidative damage in normal hepatocytes remain …
Isoorientin from Gypsophila elegans induces apoptosis in liver cancer cells via mitochondrial-mediated pathway
X Lin, J Wei, Y Chen, P He, J Lin, S Tan, J Nie… - Journal of …, 2016 - Elsevier
Ethnopharmacological relevance Gypsophila elegans has been used as a traditional herbal
medicine for treating immune disorders and chronic liver diseases in China. The aim of this …
medicine for treating immune disorders and chronic liver diseases in China. The aim of this …