Early metabolic differences between obesity-resistant and obesity-prone mice: role of adipokines
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Decreased metabolic flexibility, ie a compromised ability to adjust fuel oxidation to fuel
availability supports development of adverse consequences of obesity. The aims of this …

Indices of both carbohydrate and lipid metabolism were examined in obese (C57BL/6J
ob/ob) mice and lean controls at 4-5 months of age in both the fed and fasted condition …

Different responses to a high fat diet (HFD) can occur even within a group of animals with
the same genetic background, such as obesity-prone (OP) or obesity-resistant (OR) …

We compared, across several physiological variables, rats most and least susceptible to
develop obesity when given a high-fat diet. After 4 wk of eating a high-fat diet (60% of …

Obesity-prone (OP) rodents are used as models of human obesity predisposition. The goal
of the present study was to identify preexisting defects in energy expenditure components in …

Transgenic animals that over-or underexpress a protein of interest have been used to study
obesity development, prevention, and susceptibility to diet-induced obesity such as a high …

High phenotypic variation in diet-induced obesity in male C57BL/6J inbred mice suggests a
molecular model to investigate non-genetic mechanisms of obesity. Feeding mice a high-fat …

Diet-induced obesity is the primary determinant of the current epidemic of diabetes. We have
explored the role of genetics in this phenomenon, using C57Bl/6 (B6), 129S6/SvEvTac …

ABSTRACT A purified moderately high fat diet has been developed to examine diet-induced
obesity in rats. Male Sprague-Dawley rats were fed this or an AIN-76A diet for 15 wk and …