Microneedles (MNs) have been broadly used for transdermal delivery of a variety of drugs,
ranging from small chemicals to biological macromolecules, due to the properties of …

Transdermal delivery of therapeutic agents for cosmetic therapy is limited to small and
lipophilic molecules by the stratum corneum barrier. Microneedle technology overcomes this …

Introduction: The most conventional drug delivery systems exist with limitations such as drug
degradation, toxicity and low bioavailability. Also, hypodermic injections can cause pain …

Transdermal drug delivery is a crucial extension of drug administration routes and has been
widely acknowledged as an alternative way to traditional oral administration and …

Abstract Background Microneedles (MNs) are the utmost unique, efficient, and minimally
invasive inventions in the pharmaceutical field. Over the past decades, many scientists …

Organic and inorganic nanoparticles (NPs) have shown promising outcomes in transdermal
drug delivery. NPs can not only enhance the skin penetration of small/biomacromolecule …

Highlights•Microneedles are minimally invasive delivery systems.•Recent studies have
shown that microneedles can be reproducibly applied by patients.•No true microneedle …

The transdermal route is an excellent site for drug delivery due to the avoidance of gastric
degradation and hepatic metabolism, in addition to easy accessibility. Although offering …

Transdermal drug delivery offers a number of advantages including improved patient
compliance, sustained release, avoidance of gastric irritation, as well as elimination of pre …

The ongoing search for biodegradable and biocompatible microneedles (MNs) that are
strong enough to penetrate skin barriers, easy to prepare, and can be translated for clinical …