Background Utrophin is the autosomal homolog of dystrophin, the product of the Duchenne
Muscular Dystrophy (DMD) locus. Its regulation is of therapeutic interest as its …

A series of novel 2-arylbenzoxazoles that upregulate the production of utrophin in murine
H2K cells, as assessed using a luciferase reporter linked assay, have been identified. This …

Duchenne muscular dystrophy (DMD) is a severe neuromuscular disorder caused by
mutations in the dystrophin gene that result in the absence of functional protein. Antisense …

Utrophin is a large protein which accumulates at the neuromuscular synapse and
myotendinous junctions in adult skeletal muscle, and is widely expressed in several non …

Duchenne muscular dystrophy is a relatively common'rare disorder,'with an incidence of
about 1/5,000 males worldwide. The responsible gene and deficient protein (dystrophin) …

In this study, we have sought to determine whether utrophin transcripts are targeted to a
distinct subcellular compartment in skeletal muscle cells, and have examined the role of the …

Duchenne muscular dystrophy is a devastating muscular dystrophy of childhood. Mutations
in the dystrophin gene destroy the link between the internal muscle filaments and the …

Duchenne muscular dystrophy (DMD) is an X-linked recessive muscle wasting disease
caused by the absence of a muscle cytoskeletal protein, dystrophin. Utrophin is the …

DUCHENNE muscular dystrophy (DMD) is a severe, progressive muscle-wasting disease
that causes cardiac or respiratory failure1, 2 and results in death at about 20 years of age …

Utrophin is a close homolog of dystrophin, the protein whose mutations cause Duchenne
muscular dystrophy (DMD). Utrophin is present at low levels in normal and dystrophic …