Fibrinogen enters wounds and solid tumors, where it is clotted to fibrin that may
subsequently be replaced by collagenous stroma. If, as has been suggested, the …

Abstract 125I-radiolabeled guinea pig fibrinogen was used to measure the influx (20 min)
and accumulation (18 h) of fibrinogen/fibrin in three transplantable carcinomas (Lewis lung …

Radiolabeled guinea pig fibrinogen (GPF) was used to measure fibrinogen influx and fibrin
accumulation in line 1 and line 10 hepato-(bile duct) carcinomas growing in the sc space of …

An association between cancer and the coagulation system was suggested by Trousseau
more than a century ago and initial reports of fibrin deposition in the stroma of solid tumors …

Fibrin deposition is a consistent early event in solid tumors and healing wounds and
precedes new blood vessel ingrowth in both. We now demonstrate that fibrin gels of …

A volume of data that has accumulated for over a century has suggested that fibrin may
facilitate the persistence and progression of malignancy. Techniques that have been …

Whether undertaken by pathologists, immunologist, or biochemists, studies of tumor biology
have traditionally concentrated on the malignant cells themselves, their abnormal …

In healing wounds and many solid tumors, locally increased microvascular permeability
results in extravasation of fibrinogen and its extravascular coagulation to form a fibrin gel …

Abstract Electrophoresis in 3.5% polyacrylamide gel was used to determine the patterns of
fibrinogen heterogeneity in healthy subjects, in postoperative patients and in patients with …

Extravascular, intratumoral fibrin deposition is frequently observed within and around
neoplastic tissue and has been implicated in various aspects of tumour growth. This is the …